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SML3110

Sigma-Aldrich

CRANAD-3

≥98% (HPLC)

Synonym(s):

(T-4)-[(1E,6E)-1,7-Bis[6-(diethylamino)-3-pyridinyl]-1,6-heptadiene-3,5-dionato-κO3,κO5]difluoroboron, CRANAD 3

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About This Item

Empirical Formula (Hill Notation):
C25H31BF2N4O2
CAS Number:
1561983-97-8
Molecular Weight:
468.35
UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

gray to black

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

FB(O1)(F)O=C(/C=C/C2=CN=C(N(CC)CC)C=C2)C=C1/C=C/C3=CC=C(N(CC)CC)N=C3

Biochem/physiol Actions

CRANAD-3, a curcumin analog, is a brain barrier penetrant smart NIRF (near-infrared) probe for both soluble and insoluble Aβ (amyloid beta) species in vivo. CRANAD-3 could be used to monitor the decrease in Aβs after drug treatment in transgenic AD (APP/PS1) mice. CRANAD-3 is suitable for in vivo dually-amplify signal via chemiluminescence resonance energy transfer (DAS-CRET) with ADLumin-1 a brain blood barrier penetrant smart chemiluminescence probe for Aβs

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Jing Yang et al.
Nature communications, 11(1), 4052-4052 (2020-08-15)
Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence has been rarely explored for in vivo imaging. Herein, we report the design and validation of chemiluminescence probe ADLumin-1 as a turn-on probe for amyloid beta (Aβ) species. Two-photon imaging indicates

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