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S4776

Sigma-Aldrich

Somatotropin from human pituitary

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), lyophilized powder

Synonym(s):
STH, Growth Hormone
MDL number:
NACRES:
NA.32

Quality Level

recombinant

expressed in E. coli

sterility

non-sterile

assay

≥95% (SDS-PAGE)

form

lyophilized powder

potency

0.025-0.1 ng/mL cell proliferation using Nb2-11 cells per bioactivity ED50

mol wt

predicted mol wt ~22 kDa

drug control

Home Office Schedule 4.2

impurities

endotoxin, tested

solubility

PBS: 0.100 mL, clear, colorless (with 0.1% BSA )

UniProt accession no.

shipped in

ambient

storage temp.

−20°C

Gene Information

General description

Somatotropin or growth hormone is a peptide hormone that is secreted by the anterior pituitary gland. It is essential for growth. The hormone increases muscle mass, reduces fat mass, helps in maintaining normal blood glucose levels and also promotes a balanced lipid profile.

Application

Somatotropin or growth hormone has been used to study the molecular interactions of ephrin type-A receptor 4 precursor (EphA4) with the growth hormone receptor. It has also been used to induce differentiation in mammary epithelial cell line HC11.

Biochem/physiol Actions

Increases mass of most tissues by increasing cell number rather than cell size, mobilizes fat stores.

Physical form

Lyophilized from a 0.2 μm filtered solution in TBS (20 mM Tris, 0.15 M NaCl, pH 8.5) containing 50 μg of BSA per 1 μg of cytokine.

Reconstitution

It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Product Information Sheet

Quotes and Ordering

Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: a review
Christina Southern Reh
Clinical Pharmacology & Biopharmaceutics (2010)
Lina Pednekar et al.
Frontiers in immunology, 7, 600-600 (2017-01-10)
Dendritic cells (DCs) are the most potent antigen-presenting cells capable of priming naïve T-cells. Its C-type lectin receptor, DC-SIGN, regulates a wide range of immune functions. Along with its role in HIV-1 pathogenesis through complement opsonization of the virus, DC-SIGN
Molecular interactions of EphA4, growth hormone receptor, Janus kinase 2, and signal transducer and activator of transcription 5B
Takahiro Sawada
PLoS ONE (2017)
Yun Pang et al.
Kidney international, 90(6), 1357-1367 (2016-10-18)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by overproduction of numerous autoantibodies. Many studies have sought to identify such biomarkers to distinguish patients with active lupus nephritis from SLE patients without renal involvement. Because antibodies to complement C1q
Quantitative analysis of the expression of whey acidic protein (WAP) mRNA in the prolactin-responsive mouse mammary gland epithelial cell line, HC11
Kawamata, Yuji, et al
Journal of Reproduction and Development (2001)

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