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P5669

Sigma-Aldrich

Pyridoxine

≥98%

Synonym(s):
Pyridoxol, Vitamin B6
Empirical Formula (Hill Notation):
C8H11NO3
CAS Number:
Molecular Weight:
169.18
EC Number:
MDL number:
PubChem Substance ID:

assay

≥98%

form

powder

technique(s)

HPLC: suitable

color

white to off-white

mp

159-162 °C (lit.)

SMILES string

Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3

InChI key

LXNHXLLTXMVWPM-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)

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General description

Pyridoxine (vitamin B6) is a form of vitamin B6. Other forms include the aldehyde pyridoxal and the amide pyridoxamine. It is an important cofactor for metabolism.
Vitamin B group are water-soluble and exists in six forms which includes the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phospate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Vitamin B6 is distributed in nuts, whole grains and animal meat.

Application

Pyridoxine has been used as a component of:
  • artificial diet for sugarcane aphid pest
  • modified Strullu and Romand (MSR) medium for carrot root organ culture
  • Luria broth for E coli cultures

Pyridoxine is used in cell culture and other applications as a precursor to pyridoxal phosphate. It has been used as a standard in RP-HPLC (reversed phase high performance liquid chromatography) method. Pyridoxine has been used as a diet supplement to study lipid profile in rats.

Biochem/physiol Actions

Pyridoxine plays a key role in cell maintenance and amino acid metabolism. Deficiency of vitamin B6 leads to anemia especially in pregnant women and seizures in newborns. It serves as cofactor for heme biosynthesis during δ-amino levulinic acid formation, γ-aminobutyric acid (GABA) transaminase and glutamic acid decarboxylase. Vitamin B6 also helps in reactive oxygen species (ROS) scavenging and helps plants in overcoming the abiotic and biotic stress.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

Tracking Lipid Transfer by Fatty Acid Isotopolog Profiling from Host Plants to Arbuscular Mycorrhiza Fungi
Redkar A, et al.
Bio-protocol, 8(7) (2018)
E B Rimm et al.
JAMA, 279(5), 359-364 (1998-02-12)
Hyperhomocysteinemia is caused by genetic and lifestyle influences, including low intakes of folate and vitamin B6. However, prospective data relating intake of these vitamins to risk of coronary heart disease (CHD) are not available. To examine intakes of folate and
Seizures caused by pyridoxine (vitamin B6) deficiency in adults: A case report and literature review
Tong Y
Intractable & rare diseases research, 3(2), 52-56 (2014)
Pediatric Critical Care, 306(20), 2269-2269 (2011)
Nutrition and anemia in end-stage renal disease
Nutritional Management of Renal Disease, 383-391 (2013)

Protocols

HPLC Analysis of Vitamins, Water Soluble on Discovery® C18

Separation of Pyridoxine; Nicotinamide; Nicotinic acid; Folic acid; (−)-Riboflavin, meets USP testing specifications; L-Ascorbic acid

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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