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F7876

Sigma-Aldrich

Folic acid

≥97%

Synonym(s):
PteGlu, Pteroyl-L-glutamic acid, Vitamin M
Empirical Formula (Hill Notation):
C19H19N7O6
CAS Number:
Molecular Weight:
441.40
Beilstein:
100781
EC Number:
MDL number:
eCl@ss:
34058014
PubChem Substance ID:
NACRES:
NA.79

biological source

synthetic (organic)

Quality Level

assay

≥97%

form

powder

technique(s)

HPLC: suitable

color

faint orange to dark orange-yellow
faint yellow to dark yellow

mp

>285 °C

storage temp.

room temp

SMILES string

NC(N1)=NC(C2=C1N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=O

InChI

1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI key

OVBPIULPVIDEAO-LBPRGKRZSA-N

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Application

Folic acid has been used:
  • to induce acute kidney injury in mice
[12]
  • as a supplement to cultivate MCF-7 breast cancer cells.
  • [13]
  • to construct folate or TNF-related apoptosis-including ligand (TRAIL)-conjugated nanomicelles
  • [14]

    Packaging

    1, 10, 25, 100 g in glass bottle

    Biochem/physiol Actions

    Enzyme cofactor essential for the synthesis, methylation, and repair of DNA. Folic acid supplements may reduce colorectal cancer risk.
    Folic acid (FA) and dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF), which in turn supports ‘one carbon′ transfer. Tetrahydrofolates are required for de novo synthesis of purines, thymidylic acid and various amino acids and for post-translational methylation (epigenetics).

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 1

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

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    Certificate of Origin

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    Product Information Sheet

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