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N149

Sigma-Aldrich

Nimodipine

Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester, Isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate
Empirical Formula (Hill Notation):
C21H26N2O7
CAS Number:
Molecular Weight:
418.44
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

assay

≥98% (HPLC)

Quality Level

form

powder

color

off-white to yellow

solubility

methanol: 62.5 mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble

originator

Bayer

SMILES string

COCCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OC(C)C

InChI

1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3

InChI key

UIAGMCDKSXEBJQ-UHFFFAOYSA-N

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Application

Nimodipine has been used:
  • as a L-type calcium channel (LTCC) inhibitor, to evaluate its neuroprotective activity in the vibrosections
[29]
  • as a standard, in the enantioseparation of chiral drugs by high performance liquid chromatography (HPLC)
  • [29]
  • in the pharmacological studies for the measurement of spine voltage escape
  • [53]

    Packaging

    100, 500 mg in poly bottle

    Biochem/physiol Actions

    Nimodipine enhances the survival of dopaminergic substantia nigra neurons.[29]
    Nimodipine is a potent L-type Ca2+ channel antagonist.

    Features and Benefits

    This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
    This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

    Caution

    Photosensitive

    Other Notes

    Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N149.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

    Pictograms

    Exclamation mark

    Signal Word

    Warning

    Hazard Statements

    Precautionary Statements

    Hazard Classifications

    Acute Tox. 4 Oral

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 1

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves

    Certificate of Analysis

    Enter Lot Number to search for Certificate of Analysis (COA).

    Certificate of Origin

    Enter Lot Number to search for Certificate of Origin (COO).

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