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MSKT0001

Sigma-Aldrich

SILu™MAb K1 Pharmacokinetic Kit

Synonym(s):

PK Kit

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About This Item

UNSPSC Code:
41105331
NACRES:
NA.41

suitability

suitable for mass spectrometry

storage temp.

2-8°C

Related Categories

General description

All critical reagents necessary to perform the assay are provided in the kit. The plate-based format avoids the high cost and potential LC column blockage associated with bead-based enrichment formats. Sample preparation with the SILu™MAb PK kit can be performed in under 5 hours and consists of coating wells with high-specificity capture antibody, followed by immunoaffinity enrichment and rapid, in-plate trypsin digestion. The resulting digest is ready for injection, with no SPE or other cleanup required.

Application

The SILu™MAb K1 Pharmacokinetic (PK) kit enables a robust, high-throughput assay for quantification of human IgG1 antibody in animal sera by LC-MS/MS.

Storage and Stability

Store the kit at 2-8°C. The kit is stable for two years refrigerated.

Legal Information

SILu is a trademark of Sigma-Aldrich Co. LLC

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 3 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

flash_point_f

75.2 °F

flash_point_c

24 °C

Certificates of Analysis (COA)

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Articles

Development of a Simple and Rapid Digestion Protocol for Proteomics Sample Preparation

In this study, we developed a rapid trypsin digest kit that, at elevated temperatures, yielded reliable, reproducible results in less than 2 hours on a wide variety of substrates for mass spectrometry.

Protocols

Workflow for Preclinical Monoclonal Antibody Quantification

Pharmacokinetic (PK) kit enables a robust, high-throughput assay for quantification of human IgG1 antibody in animal sera by LC-MS/MS.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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