471283

Triethylamine

≥99.5%

• Synonym(s): N,N-Diethylethanamine
• Linear Formula: (C₂H₅)₃N
• CAS Number: 121-44-8
• Molecular Weight: 101.19
• Beilstein/REAXYS Number: 605283
• EC Number: 204-469-4
• MDL number: MFCD00009051
• UNSPSC Code: 12352116
• PubChem Substance ID: 24870713
• NACRES: NA.21

Properties

• vapor density: 3.5 (vs air)
• Quality Level: 100
• vapor pressure: 51.75 mmHg ( 20 °C)
• assay: ≥99.5%
• form: liquid
• autoignition temp.: 593 °F
• expl. lim.: 8 %
• impurities: ≤0.1% (Karl Fischer)
• refractive index: n20/D 1.401 (lit.)
• pH: 12.7 (15 °C, 100 g/L)
• bp: 88.8 °C (lit.)
• mp: −115 °C (lit.)
• solubility: water: soluble 112 g/L at 20 °C
• density: 0.726 g/mL at 25 °C (lit.)
• functional group: amine
• storage temp.: room temp
• SMILES string: CCN(CC)CC
• InChI: 1S/C6H15N/c1-4-7(5-2)6-3/h4-6H2,1-3H3
• InChI key: ZMANZCXQSJIPKH-UHFFFAOYSA-N

Description

General description

Triethylamine (TEA, Et₃N) is an aliphatic amine. Its addition to matrix-assisted laser desorption/ionization (MALDI) matrices affords transparent liquid matrices with enhanced ability for spatial resolution during MALDI mass spectrometric (MS) imaging. A head-space gas chromatography (GC) procedure for the determination of triethylamine in active pharmaceutical ingredients has been reported. The viscosity coefficient of triethylamine vapor over a range of density and temperature has been measured.

Application

Triethylamine has been used during the synthesis of:

• 5′-dimethoxytrityl-5-(fur-2-yl)-2′-deoxyuridine
• 3′-(2-cyanoethyl)diisopropylphosphoramidite-5′-dimethoxytrityl-5-(fur-2-yl)-2′-deoxyuridine
• polyethylenimine600-β-cyclodextrin (PEI₆₀₀-β-CyD)

It may be used as a homogeneous catalyst for the preparation of glycerol dicarbonate, via transesterification reaction between glycerol and dimethyl carbonate (DMC).

Packaging

18 L packaged in closed-head steel drums; 100 mL, 500 mL, 2 L, 6×500 mL, 4 L packaged in glass bottles; 200 L packaged in Kilo-Lab^® steel cylinders

Legal Information

Pure-Pac is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS06,GHS05
• signalword: Danger
• hcodes: H225,H302,H311 + H331,H314,H335
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 12.2 °F - closed cup
• flash_point_c: -11 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter