MilliporeSigma
All Photos(3)

M5005

Sigma-Aldrich

Manganese(II) chloride tetrahydrate

BioReagent, suitable for insect cell culture

Linear Formula:
MnCl2 · 4H2O
CAS Number:
Molecular Weight:
197.91
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

product line

BioReagent

assay

≥99% (by AgNO3, titration)

technique(s)

cell culture | insect: suitable

mp

58 °C (lit.)

SMILES string

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

InChI key

CNFDGXZLMLFIJV-UHFFFAOYSA-L

Looking for similar products? Visit Product Comparison Guide

Application

Manganese(II) chloride tetrahydrate has been used:
  • as trace element in the fungal complete medium
  • as a supplement in the culture medium for cochlear organotypic culture
  • to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice

Packaging

100, 500 g in poly bottle

Biochem/physiol Actions

Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 2 - Eye Dam. 1 - STOT RE 2

Target Organs

Brain

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Agrobacterium-mediated transformation of the filamentous fungus Aspergillus awamori.
Michielse CB, et al.
Nature Protocols, 3(10), 1671-1671 (2008)
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service