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Methyllycaconitine citrate salt

from Delphinium brownii seeds, ≥96% (HPLC)

MLA, [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt
Empirical Formula (Hill Notation):
C37H50N2O10 · xC6H8O7
CAS Number:
Molecular Weight:
682.80 (salt-free basis)
MDL number:
PubChem Substance ID:

biological source

Delphinium brownii seeds

Quality Level


≥96% (HPLC)




H2O: 42 mg/mL

storage temp.


SMILES string




InChI key



Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:
  • to study its effects on inflammatory response in rats post nicotine treatment
  • to block the activity of galantamine
  • to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats


5, 25 mg in glass bottle

Biochem/physiol Actions

Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium. MLA binds to the binding site of neuronal α-bungarotoxin. Low doses of MLA are associated with improvement of cognition in animals.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

13 - Non Combustible Solids



Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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Matthew Townsend et al.
Journal of neurophysiology, 116(6), 2663-2675 (2016-09-23)
Agonists of the α7-nicotinic acetylcholine receptor (α7-nAChR) have entered clinical trials as procognitive agents for treating schizophrenia and Alzheimer's disease. The most advanced compounds are orthosteric agonists, which occupy the ligand binding site. At the molecular level, agonist activation of
Cecília Cerqueira Café-Mendes et al.
Neuroscience letters, 636, 218-224 (2016-12-17)
The hippocampus is a brain region that is rich in nicotinic acetylcholine receptors (nAChRs), especially the α7 subtype. The hippocampus is severely affected in disorders that have a neuroinflammatory component, such as Alzheimer's disease, Parkinson's disease, and schizophrenia. Previous studies
Natalia Pinilla-Echeverri et al.
Circulation. Cardiovascular interventions, 13(7), e008768-e008768 (2020-07-11)
Complete revascularization with routine percutaneous coronary intervention of nonculprit lesions after primary percutaneous coronary intervention improves outcomes in ST-segment-elevation myocardial infarction. Whether this benefit is associated with nonculprit lesion vulnerability is unknown. In a prospective substudy of the COMPLETEs trial
Elizabeth Glenn Guy et al.
Psychopharmacology, 225(2), 429-440 (2012-08-14)
Stimuli associated with nicotine can become motivationally significant and may play a role in tobacco dependence. Previous work indicates that nicotine enhances responding for a conditioned reinforcer (CR). These studies examined the effects of prior exposure to nicotine on responding
Francesca Prestori et al.
PloS one, 8(5), e64828-e64828 (2013-06-07)
The brain needs mechanisms able to correlate plastic changes with local circuit activity and internal functional states. At the cerebellum input stage, uncontrolled induction of long-term potentiation or depression (LTP or LTD) between mossy fibres and granule cells can saturate

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