MilliporeSigma
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N5636

Sigma-Aldrich

3-Nitropropionic acid

≥97%

Linear Formula:
O2N(CH2)2CO2H
CAS Number:
Molecular Weight:
119.08
Beilstein:
1759889
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.77

biological source

synthetic

Quality Level

assay

≥97%

form

powder or crystals

color

white to light yellow

mp

68-70 °C (lit.)

solubility

alcohol: may be light yellow 100 mg/mL

storage temp.

2-8°C

SMILES string

OC(CC[N+]([O-])=O)=O

InChI

1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)

InChI key

WBLZUCOIBUDNBV-UHFFFAOYSA-N

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Application

3-Nitropropionic acid has been used:
  • to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
  • to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
  • as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines

Packaging

10 g in poly bottle

Biochem/physiol Actions

Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II.
Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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