Skip to Content
MilliporeSigma
All Photos(1)

Key Documents

View All Documentation

I6891

Sigma-Aldrich

H-7

Synonym(s):

1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, Isoquinoline-5-sulfonic 2-methyl-1-piperazide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C14H17N3O2S
CAS Number:
84477-87-2
Molecular Weight:
291.37
Beilstein/REAXYS Number:
5482740
MDL number:
MFCD00063403
UNSPSC Code:
12352200
PubChem Substance ID:
24896097
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

mp

114 °C

solubility

ethanol: 20 mg/mL
1 M HCl: 5 mg/mL

storage temp.

2-8°C

SMILES string

CC1CNCCN1S(=O)(=O)c2cccc3cnccc23

InChI

1S/C14H17N3O2S/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14/h2-6,10-11,16H,7-9H2,1H3

InChI key

BDVFVCGFMNCYPV-UHFFFAOYSA-N

Gene Information

human ... CALCRL(10203)
rat ... Calcrl(25029)

Looking for similar products? Visit Product Comparison Guide

Biochem/physiol Actions

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chunyun Liu et al.
PloS one, 8(2), e54841-e54841 (2013-02-19)
We observed the therapeutic effect of Fasudil and explored its mechanisms in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Fasudil, a selective Rho kinase (ROCK) inhibitor, was injected intraperitoneally at 40 mg/kg/d in early and late
Clarisse Thiollier et al.
The Journal of experimental medicine, 209(11), 2017-2031 (2012-10-10)
Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease generally associated with poor prognosis. Gene expression profiles indicate the existence of distinct molecular subgroups, and several genetic alterations have been characterized in the past years, including the t(1;22)(p13;q13) and the trisomy
Alice Bayiyana et al.
Journal of fungi (Basel, Switzerland), 5(3) (2019-07-20)
Despite improvement in the prognosis of HIV/AIDS (human immunodeficiency virus/acquired immune deficiency syndrome) patients on antiretroviral therapy (ART), cryptococcal meningitis (CM) still causes 10-15% mortality among HIV-infected patients. The immunological impact of ART on the CD4+ and CD8+ T cell
Torben Gehring et al.
Cell reports, 29(4), 873-888 (2019-10-24)
The CARMA1/CARD11-BCL10-MALT1 (CBM) complex bridges T and B cell antigen receptor (TCR/BCR) ligation to MALT1 protease activation and canonical nuclear factor κB (NF-κB) signaling. Using unbiased mass spectrometry, we discover multiple serine phosphorylation sites in the MALT1 C terminus after
Ashraf A Aly et al.
Molecules (Basel, Switzerland), 24(20) (2019-10-24)
Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-c:5,6-c']difuro[2,3-c:4,5-c']-diquinoline-6,14(5H,12H)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[d]oxazol-2-yl)-3-hydroxy-1H-[4,5]oxazolo[3,2-a]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service