H6501

DL-β-Hydroxybutyric acid sodium salt

~98%, powder

• Synonym(s): (±)-3-Hydroxybutanoic acid sodium salt
• Linear Formula: C₄H₇O₃Na
• CAS Number: 150-83-4
• Molecular Weight: 126.09
• EC Number: 205-774-5
• MDL number: MFCD00016716
• UNSPSC Code: 12352204
• PubChem Substance ID: 24895744
• NACRES: NA.83

Properties

• product name: DL-β-Hydroxybutyric acid sodium salt, ~98%
• assay: ~98%
• form: powder
• solubility: water: 1 g/10 mL, clear, colorless
• storage temp.: 2-8°C
• SMILES string: [Na].CC(O)CC(O)=O
• InChI: 1S/C4H8O3.Na/c1-3(5)2-4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1
• InChI key: NBPUSGBJDWCHKC-UHFFFAOYSA-M

Description

Application

DL-β-Hydroxybutyric acid sodium salt has been used:

• as a standard for quantifying blood plasma and milk β-hydroxybutyric acid in Danish Jersey cows
• to investigate its anticonvulsant effects in epilepsy induced rats
• to induce hyperketonemia in Holstein dairy cows

Biochem/physiol Actions

β-Hydroxybutyric acid is a ketone body present in the rumen epithelium of liver cells. Its interconversion to acetoacetate influences the acid-base balance and is coupled NADH generation from (nicotinamide adenine dinucleotide) NAD⁺, measured fluorimetrically. A high plasma level of β-hydroxybutyric acid is implicated in diabetic ketoacidosis. It traverses the blood-brain barrier as a monocarboxylic acid. β-Hydroxybutyric acid may play a protective role in dopaminergic neurodegeneration in Parkinson′s disease model. β-Hydroxybutyric acid is a ligand for G protein-coupled receptor(GPR109A) and favors inhibition of secretion, transcription and translation of growth hormone (GH) and prolactin (PRL) gene in cow anterior pituitary cells (DCAPCs).

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)