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C6594

Sigma-Aldrich

Monoclonal Anti-c-Myc−Cy3™ antibody produced in mouse

clone 9E10, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-c-Myc

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

CY3 conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

9E10, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

direct immunofluorescence: 1:50 using formalin-fixed, paraffin-embedded human colon carcinoma tissue

UniProt accession no.

P01106

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... MYC(4609)

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General description

Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse. The c-Myc gene encodes a polypeptide with a predicted molecular weight of 49 kDa.

Immunogen

synthetic peptide of the human p62c-Myc protein.

Application

Monoclonal Anti-c-MycCy3™ antibody produced in mouse has been used in:
  • western blotting
  • immunocytochemistry
  • Immunofluorescence

Biochem/physiol Actions

The encoded protein is involved in cell proliferation, growth and apoptosis. The c-myc gene has been implicated in the development of a number of neoplasms in a variety of avian and mammalian species. The human c-myc protooncogene is the cellular homolog of the avian v-myc gene found in several leukemogenic retroviruses. Increased expression of the cellular oncogene c-myc has been described in a variety of human tumors, occurring by several different mechanisms, including gene amplification and chromosomal translocation.

Physical form

Solution in 0.01 M sodium phosphate buffered saline containing 1% bovine serum albumin and 15 mM sodium azide.

Legal Information

Cy3 is a trademark of Cytiva

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nir London et al.
Biochemistry, 51(29), 5841-5850 (2012-06-19)
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Journal of molecular biology, 398(5), 747-762 (2010-04-07)
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