04260

All Photos(1)

04260

N-Ethylmaleimide

purum p.a., ≥99.0% (HPLC)

All Photos(1)

Synonym(s):

NEM

Empirical Formula (Hill Notation):

C₆H₇NO₂

CAS Number:

128-53-0

Molecular Weight:

125.13

Beilstein:

112448

EC Number:

204-892-4

MDL number:

MFCD00005509

PubChem Substance ID:

329747901

NACRES:

NA.26

grade

purum p.a.

Quality Level

200

Assay

≥99.0% (HPLC)

ign. residue

≤0.05%

bp

210 °C (lit.)

mp

43-46 °C (lit.)
43-46 °C

anion traces

chloride (Cl^-): ≤50 mg/kg
sulfate (SO₄^2-): ≤100 mg/kg

cation traces

Ca: ≤50 mg/kg
Cd: ≤50 mg/kg
Co: ≤50 mg/kg
Cu: ≤50 mg/kg
Fe: ≤50 mg/kg
K: ≤100 mg/kg
Na: ≤100 mg/kg
Ni: ≤50 mg/kg
Pb: ≤50 mg/kg
Zn: ≤50 mg/kg

storage temp.

2-8°C

SMILES string

CCN1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChI key

HDFGOPSGAURCEO-UHFFFAOYSA-N

Gene Information

human ... SLC6A3(6531) , SLC6A4(6532)

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This Item	34115-M	E3876	E1271
Sigma-Aldrich 04260 N-Ethylmaleimide	Millipore 34115-M N-Ethylmaleimide	Sigma-Aldrich E3876 N-Ethylmaleimide	Sigma-Aldrich E1271 N-Ethylmaleimide
assay ≥99.0% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
mp 43-46 °C (lit.)	mp -	mp 43-46 °C (lit.)	mp 43-46 °C (lit.)
cation traces Ca: ≤50 mg/kg, Cd: ≤50 mg/kg, Co: ≤50 mg/kg, Cu: ≤50 mg/kg, Fe: ≤50 mg/kg, K: ≤100 mg/kg, Na: ≤100 mg/kg, Ni: ≤50 mg/kg, Pb: ≤50 mg/kg, Zn: ≤50 mg/kg	cation traces -	cation traces -	cation traces Al: ≤0.0005%, Ca: ≤0.0005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%
storage temp. 2-8°C	storage temp. 10-30°C	storage temp. 2-8°C	storage temp. 2-8°C
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
Gene Information human ... SLC6A3(6531), SLC6A4(6532)	Gene Information -	Gene Information human ... KCNQ2(3785), KCNQ4(9132), KCNQ5(56479), SLC6A3(6531), SLC6A4(6532)	Gene Information human ... SLC6A3(6531), SLC6A4(6532)

Application

N-Ethylmaleimide has been used to measure low molecular weight thiols bound to plasma proteins.

Reagent for the covalent modification of cysteine residues in proteins.

Biochem/physiol Actions

Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.

Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

Pictograms

GHS05,GHS06

Signal Word

Danger

Hazard Statements

H300 - H311 - H314 - H317

Precautionary Statements

P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

163.2 °F

Flash Point(C)

72.9 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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