PHR1052

Metronidazole

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): MTZ, 2-Methyl-5-nitroimidazole-1-ethanol
• Empirical Formula (Hill Notation): C₆H₉N₃O₃
• CAS Number: 443-48-1
• Molecular Weight: 171.15
• Beilstein: 611683
• EC Number: 207-136-1
• MDL number: MFCD00009750
• PubChem Substance ID: 329823082

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to BP 603; traceable to Ph. Eur. M1850000; traceable to USP 1442009
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 159-161 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CC1=NC=C([N+]([O-])=O)N1CCO
• InChI: 1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
• InChI key: VAOCPAMSLUNLGC-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Metronidazole is a 5-nitroimidazole derivative that is an effective agent against the diseases caused by anaerobic protozoa and bacteria. It is known to exert radio-sensitizing impact on hypoxic tumour cells.

Application

Metronidazole may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0264 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS08
• Signal Word: Danger
• Hazard Statements: H340 - H350 - H373
• Precautionary Statements: P201 - P202 - P260 - P280 - P308 + P313 - P405
• Hazard Classifications: Carc. 1B - Muta. 1B - STOT RE 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3