I3377

Isoniazid

analytical standard, ≥99% (TLC)

• Synonym(s): INH, 4-Pyridinecarboxylic acid hydrazide, Isonicotinic acid hydrazide, Isonicotinic hydrazide
• Empirical Formula (Hill Notation): C₆H₇N₃O
• CAS Number: 54-85-3
• Molecular Weight: 137.14
• Beilstein/REAXYS Number: 119374
• EC Number: 200-214-6
• MDL number: MFCD00006426
• PubChem Substance ID: 329815370
• NACRES: NA.24

Properties

• Quality Level: 100
• grade: analytical standard
• assay: ≥99% (TLC)
• form: neat
• application(s): HPLC: suitable; gas chromatography (GC): suitable
• mp: 171-173 °C (lit.)
• fluorescence: λ_ex 360 nm; λ_em 450 nm (thiol adduct)
• Featured Industry: Forensics and Toxicology; Pharmaceutical (small molecule)
• antibiotic activity spectrum: mycobacteria
• format: neat
• SMILES string: NNC(=O)c1ccncc1
• InChI: 1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)
• InChI key: QRXWMOHMRWLFEY-UHFFFAOYSA-N

Description

General description

Isoniazid is a type of drug possessing antimycobacterial activity.It is used in the treatment of tuberculosis.

Chemical structure: pyridine

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Packaging

5, 50, 250 g in poly bottle

Biochem/physiol Actions

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 - H315
• Precautionary Statements: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313
• hazcat: Acute Tox. 4 Oral - Skin Irrit. 2
• storage_class_code: 11 - Combustible Solids
• WGK Germany: WGK 3
• Personal Protective Equipment: dust mask type N95 (US),Eyeshields,Gloves