557303

Rifampicin - CAS 13292-46-1 - Calbiochem

Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex.

• Synonym(s): Rifampicin - CAS 13292-46-1 - Calbiochem, Rifampin, 3-(4-Methylpiperazinyliminomethyl)rifamycin SV
• Empirical Formula (Hill Notation): C₄₃H₅₈N₄O₁₂
• CAS Number: 13292-46-1
• Molecular Weight: 822.94
• MDL number: MFCD00151389

Properties

• Quality Level: 100
• assay: ≥97% (by Assay)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: brown-red to brick red
• solubility: DMSO: 25 mg/mL; methanol: 25 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C

Description

General description

Antibiotic that specifically inhibits DNA-dependent RNA polymerase in bacteria by forming an inactive complex. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Antibiotic that specifically inhibits DNA-dependent bacterial RNA polymerase by forming an inactive complex with RNA polymerase. Does not affect mammalian RNA polymerase. Inhibits transcription by preventing the initial transcription complex from entering the elongation mode.

Packaging

5 g in Plastic ampoule

Biochem/physiol Actions

Primary Target
DNA-dependent RNA polymerase in bacteria

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 2 months at -20°C.

Other Notes

Jin, D.J. and Turnbough, Jr., C.L. 1994. J. Mol. Biol. 236, 72.
Levin, M.E. and Hatfull, G.F. 1993. Mol. Microbiol. 8, 277.
Wehrli, W., et al. 1968. Proc. Natl. Acad. Sci. USA61, 667.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 - H315 - H319 - H335 - H362
• Precautionary Statements: P260 - P263 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable