All Photos(1)

75035

Supelco

Mettler-Toledo Calibration substance ME 18872, Caffeine

analytical standard, for the calibration of the thermosystem 900, traceable to primary standards (LGC)

Synonym(s):
Caffeine, 1,3,7-Trimethylxanthine
Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
Molecular Weight:
194.19
Beilstein:
17705
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

form

neat

quality

traceable to primary standards (LGC)

shelf life

limited shelf life, expiry date on the certificate and label

mp

234-236.5 °C (lit.)

Featured Industry

Cleaning Products
Food and Beverages
Personal Care
Pharmaceutical

format

neat

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Caffeine Mettler-Toledo melting point standard is useful for the routine calibration of Mettler-Toledo melting point instrument. The value for its melting point equals an average of 6 to 12 measurements with a Mettler-Toledo MP70 excellence melting point instrument that is calibrated with primary standards.

Application

Mettler-Toledo calibration standard ME 18872, caffeine (234-236.5 °C) finds its use in the calibration of thermosystem 900, in both pharmacopeia and thermodynamic modes of operation.
This mp standard is also employed as a temperature calibration standard in thermal analysis techniques.

Biochem/physiol Actions

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

Features and Benefits

  • Melting point calibration standard traceable to a primary standard from LGC, London
  • Melting points measured in both thermodynamic and pharmacopeia modes
  • Available with certificates of analysis and safety data sheet
  • A product of analytical standard grade that meets the QC/QA requirements of melting point analysis
  • Ready-to-use melting point standard, supplied as a finely ground powder

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

13 - Non Combustible Solids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Are the Mettler-Toledo Calibration melting standards already dried and pulverized, ready to use out of the bottle?

    The answer is yes. All melting point standards are ground to a fine powder, tested as melting point standards and ready to use.

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Co-crystals of diflunisal and isomeric pyridinecarboxamides?a thermodynamics and crystal engineering contribution
Evora.L.OA, et al.
CrystEngComm, 18(25), 4749-4759 (2016)
Markus Fehrholz et al.
American journal of physiology. Lung cellular and molecular physiology, 306(1), L101-L109 (2013-10-29)
Factors positively influencing surfactant homeostasis in general and surfactant protein B (SP-B) expression in particular are considered of clinical importance regarding an improvement of lung function in preterm infants. The objective of this study was to identify effects of physiological...
France Denoeud et al.
Science (New York, N.Y.), 345(6201), 1181-1184 (2014-09-06)
Coffee is a valuable beverage crop due to its characteristic flavor, aroma, and the stimulating effects of caffeine. We generated a high-quality draft genome of the species Coffea canephora, which displays a conserved chromosomal gene order among asterid angiosperms. Although...
Jonathan M Hodgson et al.
The American journal of clinical nutrition, 97(5), 943-950 (2013-04-05)
Measures of blood pressure variation have been associated with cardiovascular disease and related outcomes. The regular consumption of black tea can lower blood pressure, but its effects on blood pressure variation have yet to be investigated. We aimed to assess...
Louise A Horrigan et al.
Pharmacology & therapeutics, 111(3), 877-892 (2006-03-17)
Caffeine is a member of the methylxanthine family of drugs, and is the most widely consumed behaviourally active substance in the western world. This article is focused on the impact of caffeine on immune function. In this regard, a number...

Articles

HPLC Analysis of Pain Relievers on Ascentis® Express C18

Separation of Acetaminophen, meets USP testing specifications, 98.0-102.0%, powder; Caffeine, meets USP testing specifications, anhydrous; Benzoic acid, meets USP testing specifications; Aspirin, meets USP testing specifications

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service