1.03 (vs air)
<1.45 mmHg ( 25 °C)
120-170 °C (lit.)
0.88 g/mL at 25 °C (lit.)
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Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Eye Dam. 1 - Flam. Sol. 2 - Muta. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
4.1B - Flammable solid hazardous materials
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
Paraformaldehyde is the polymeric form of formaldehyde. It is a solid. Formaldehyde is a gas which when dissolved in water gives a formaldehyde solution. Commercially available formaldehyde solutions usually contain 10-15% methanol, which prevents the formaldehyde from forming the polymeric paraformaldehyde.
Prilled has the appearance of small white beads. Product 158127 is a powder, not prilled.
Paraformaldehyde does not dissolve but rather can be depolymerized in solution. Depolymerized solutions can be prepared in water with heating to 55-60°C. If necessary, further addition of 1-2 drops of a sodium hydroxide solution may be required. Some protocols suggest that paraformaldehyde should be prepared in buffered solutions such as phosphate buffer or PBS at approximately pH 7.
Buffered solutions of 2-4% formaldehyde may be used for up to two weeks if stored in brown bottles at 2-8°C.
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
Product 16005 is sold only in Europe and is not available to US customers.The primary differences among the various products is in the form for each product. P6148 is listed as crystalline, 158127 is listed as powder, and 441244 is listed as prilled. The product information page for 441244 states the prilled form will go into solution more readily, but the prilled, crystalline, and powder forms are equivalent in terms on use. The prilled form is expected to slow down the rate of sublimation compared to the powder or the crystalline forms. Any of the 3 products should be suitable for use as a fixative. However, once prepared, paraformaldehyde solutions are unstable unless methanol is added as a stabilizer. Customer options vary from preparing solutions daily to storing solutions for 2 or 3 weeks. If used as a fixative for electron microscopy, we recommend preparing solutions fresh daily to avoid the risk of repeating tedious EM work due to deterioration of the fixative. For less critical applications, it would be more acceptable to use solutions stored for longer periods of time.
Ask a Scientist here.
This protocol describes a method for chemical cross-linking of proteins using formaldehyde. With the exception of zero-length cross-linkers, formaldehyde has the shortest cross-linking span (~2-3 Å) of any cross-linking reagent, thus making it an ideal tool for detecting specific protein-protein interactions with great confidence.