15269

N,O-Bis(trimethylsilyl)acetamide

for GC derivatization, LiChropur^™, ≥98.5% (GC)

• Synonym(s): BSA
• Linear Formula: CH₃C[=NSi(CH₃)₃]OSi(CH₃)₃
• CAS Number: 10416-59-8
• Molecular Weight: 203.43
• Beilstein/REAXYS Number: 1306669
• EC Number: 233-892-7
• MDL number: MFCD00008270
• UNSPSC Code: 41116105
• PubChem Substance ID: 329750807
• NACRES: NA.22

Properties

• grade: for GC derivatization
• Quality Level: 100
• assay: ≥98.5% (GC)
• form: liquid
• quality: LiChropur^™
• reaction suitability: reagent type: derivatization reagent; reaction type: Silylations
• technique(s): gas chromatography (GC): suitable
• refractive index: n20/D 1.417 (lit.); n20/D 1.417
• bp: 71-73 °C/35 mmHg (lit.)
• density: 0.832 g/mL at 20 °C (lit.)
• SMILES string: C\C(O[Si](C)(C)C)=N/[Si](C)(C)C
• InChI: 1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+
• InChI key: SIOVKLKJSOKLIF-CMDGGOBGSA-N

Description

General description

N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.

Application

Learn more in the Product Information

Suitable for the derivatization of 2-amino-2-dexoxyhexoses, ecdysones, hexosamines in glycosaminoglycans, 18-hydroxycorticosteroids, 15-Oxo-prostaglandin F_2α, prostaglandins A,B and E and F, F_2α, prostaglandins and metabolites, prostaglandins Emetabolites, sugar phosphates, steroids and testosterone.

Other Notes

Powerful silylating agent

Reagent for o-trimethylsilyl-aldono-1,4-lactones, trimethylsilyl and trimethylsilyl ether.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• pictograms: GHS02,GHS05,GHS07
• signalword: Danger
• hcodes: H226,H302,H314
• pcodes: P210 - P233 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B
• supp_hazards: EUH014
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 111.2 °F - closed cup
• flash_point_c: 44 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges