30-3670
D-(+)-Trehalose dihydrate
SAJ special grade, ≥99.0%
Synonym(s):
α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside
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About This Item
Empirical Formula (Hill Notation):
C12H22O11 · 2H2O
CAS Number:
Molecular Weight:
378.33
Beilstein/REAXYS Number:
5322018
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
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grade
SAJ special grade
assay
≥99.0%
form
solid
availability
available only in Japan
SMILES string
[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI
1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
InChI key
DPVHGFAJLZWDOC-PVXXTIHASA-N
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Application
- Explanation and prediction for the product of trehalose dihydrate selective dehydration process using mid-frequency Raman difference spectra.: This research employs mid-frequency Raman difference spectra to analyze and predict the products formed during the selective dehydration of D-(+)-Trehalose dihydrate, providing insights into its structural changes during the dehydration process (Fan et al., 2024).
- Physico-geometrical Kinetic Aspects of the Thermal Dehydration of Trehalose Dihydrate.: This study investigates the kinetic and geometrical aspects of the thermal dehydration of D-(+)-Trehalose dihydrate, offering detailed understanding of its stability and transformation under thermal conditions (Hara et al., 2022).
- Trehalose and its dihydrate: terahertz insights from solid to solution states.: Utilizing terahertz time-domain spectroscopy, this paper explores the spectral characteristics of D-(+)-Trehalose dihydrate in both solid and solution states, comparing its behaviors and providing a comprehensive analysis through density functional theory simulations (Zhang et al., 2024).
- Oiling out and Solubility of Trehalose Dihydrate in Water + Isopropanol/1-Propanol/tert-Butanol Solvents from 283.15 to 328.15 K.: This research examines the solubility and oiling out behavior of D-(+)-Trehalose dihydrate in various solvent mixtures over a range of temperatures, providing valuable data for its application in different solvent systems (Yu et al., 2020).
Storage Class
11 - Combustible Solids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Alan Twomey et al.
International journal of pharmaceutics, 487(1-2), 91-100 (2015-04-19)
In frozen and lyophilized systems, the biological to be stabilized (e.g. therapeutic protein, biomarker, drug-delivery vesicle) and the cryo-/lyo-protectant should be co-localized for successful stabilization. During freezing and drying, many factors cause physical separation of the biological from the cryo-/lyo-protectant
Sabine Ullrich et al.
Journal of pharmaceutical sciences, 104(6), 2040-2046 (2015-04-03)
The importance of cake adhesion to the inside vial wall during lyophilization of amorphous trehalose cakes was determined by using hydrophobized vials. The degrees of cake shrinkage and cracking were determined independently by photographic imaging of the cake top surface
Joachim Schaefer et al.
International journal of pharmaceutics, 489(1-2), 124-130 (2015-05-06)
The inactivation of catalase during spray-drying over a range of outlet gas temperatures could be closely represented by the Arrhenius equation. From this an activation energy for damage to the catalase could be calculated. The close fit to Arrhenius suggests
Anke Sass et al.
Drug development and industrial pharmacy, 40(6), 749-757 (2013-04-20)
The spray-drying behaviour of 16 water-miscible organic solvents on a bench-scale machine (Büchi B290 with inert loop) was determined under mild-to-moderate process conditions, namely inlet gas temperature of 130 °C and liquid feed flow rate of ≤3 mL/min. The solvents with boiling
Shing Fung Chow et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 436-449 (2015-07-06)
The influence of critical operating parameters on the Flash Nanoprecipitation (FNP) and resulting material properties of curcumin (CUR) nanoparticles has been evaluated using a confined impinging jets-with-dilution mixer (CIJ-D-M). It has been shown that the mixing rate, molecular weight of
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