420321

KT5823

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

• Synonym(s): KT5823, PKG Inhibitor VII
• Empirical Formula (Hill Notation): C₂₉H₂₅N₃O₅
• CAS Number: 126643-37-6
• Molecular Weight: 495.53
• MDL number: MFCD09878278
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 1 mg/mL; DMF: soluble
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
• InChI key: QTYMDECKVKSGSM-YMUMJAELSA-N

Description

General description

Highly specific cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM). Inhibits protein kinase C (K_i = 4.0 µM) and protein kinase A (K_i >10.0 µM) at higher concentrations.

Highly specific, cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase G (K_i = 234 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
PKG

Product competes with ATP.

Reversible: yes

Target K_i: 234 nM against protein kinase G

Warning

Toxicity: Standard Handling (A)

Preparation Note

Further dilute with aqueous buffers just prior to use.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Grider, J.R. 1993. Am. J. Physiol.264, G334.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable