SML1614

Rp-8-Br-cGMPS sodium salt

≥98% (HPLC)

• Synonym(s): Rp-8-Bromo-cGMPS sodium salt, Rp-8-Bromoguanosine- 3′, 5′- cyclic monophosphorothioate sodium salt
• Empirical Formula (Hill Notation): C₁₀H₁₀BrN₅O₆PS · Na
• CAS Number: 208445-06-1
• Molecular Weight: 462.15
• MDL number: MFCD04037242
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825500
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: lyophilized solid
• color: white to beige
• storage temp.: −20°C
• SMILES string: O=C1C2=C(N([C@@H]3O[C@H](CO[P@@](O4)([O-])=S)[C@@H]4[C@H]3O)C(Br)=N2)N=C(N)N1.[Na+]
• InChI: 1S/C10H11BrN5O6PS.Na/c11-9-13-3-6(14-10(12)15-7(3)18)16(9)8-4(17)5-2(21-8)1-20-23(19,24)22-5;/h2,4-5,8,17H,1H2,(H,19,24)(H3,12,14,15,18);/q;+1/p-1/t2-,4-,5-,8-,23-;/m1./s1
• InChI key: CHTSSROWUAICIL-GMKUFTCMSA-M

Description

Biochem/physiol Actions

Rp-8-bromo-cGMPS is a cell permeable cGMP analog that blocks cGMP-dependent protein kinase (cGK, G-kinase, Protein Kinase G, PKG). Rp-8-bromo-cGMPS is resistant to hydrolysis by phosphodiesterases and binds cGK without activating it, resulting in competitive inhibition.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable