07-413
Anti-dimethyl-Arginine Antibody, symmetric (SYM11)
Upstate®, from rabbit
Synonym(s):
Anti-SYM11, Anti-dimethyl-Arginine, Symmetric Dimethyl-Arginine Ab
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
shipped in
dry ice
target post-translational modification
unmodified
General description
Symmetrical dimethylated arginine (sDMA) is a product of the post-translational modification, arginine methylation. sDMA is a structural isomer of asymmetric dimethylarginine.
Specificity
SmD3 at ~16kDa, and other proteins that contain arginines that are symmetrically dimethylated
Immunogen
peptide corresponding to amino acids 99-119 of Small nuclear ribonucleoprotein SmD3.
Application
Anti-dimethyl-Arginine Antibody, symmetric (SYM11) has been used in:
- co-immunoprecipitation (co-IP)
- western blot analysis
- immunoprecipitation
Biochem/physiol Actions
Symmetrical dimethylarginine (sDMA) is a competitor of arginine transport and is eliminated through renal excretion. sDMA serves as a marker to indicate the estimated glomerular filtration rate (GFR) and the coronary artery disease (CAD) severity. Elevated sDMA is associated with the risk of cardiovascular disease and mortality. It might also help in the early detection of chronic kidney disease. sDMA acts as an endogenous marker of renal function. It is associated with tumorigenesis.
Quality
routinely evaluated by immunoblot in RIPA lysates from Jurkat cells
Target description
~16 kDa
Physical form
Format: Purified
Analysis Note
Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
Certificates of Analysis (COA)
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Jérémy Dufourt et al.
Nature communications, 8(1), 1305-1305 (2017-11-05)
Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine (Aub). Aub targets
Ming Gao et al.
EMBO reports, 16(3), 379-386 (2015-01-21)
Germ cells give rise to all cell lineages in the next-generation and are responsible for the continuity of life. In a variety of organisms, germ cells and stem cells contain large ribonucleoprotein granules. Although these particles were discovered more than
Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.
Deng, X; Gu, L; Liu, C; Lu, T; Lu, F; Lu, Z; Cui, P; Pei, Y; Wang, B; Hu, S; Cao, X
Proceedings of the National Academy of Sciences of the USA null
Hao Yang et al.
Oncotarget, 7(44), 72131-72147 (2016-10-07)
Although cancer cells are known to be "addicted" to glucose, the effect of glucose in proliferation of these cells remains elusive. Here, we report that upon glucose induction, protein arginine methyltransferase 5 (PRMT5) exerts a profound effect on the G1-S
Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing.
Boisvert, Francois-Michel, et al.
The Journal of cell biology, 159, 957-969 (2002)
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