900605

3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

≥95%

• Synonym(s): Bromo sulfonyl fluoride alkyne, Probe building block
• Empirical Formula (Hill Notation): C₁₂H₁₄BrFO₂SSi
• CAS Number: 2088829-12-1
• Molecular Weight: 349.29
• UNSPSC Code: 12352200
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: ≥95%
• form: solid
• reaction suitability: reaction type: click chemistry
• storage temp.: −20°C

Description

Application

3-(Bromomethyl)-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifuctional Probe Building Blocks

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable