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900610

Sigma-Aldrich

Hydroxyl di-benzophenone (PEG)3 alkyne

Synonym(s):

4-(4-((2-(2-(2-(4-(4-(Prop-2-yn-1-yloxy)benzoyl)phenoxy)ethoxy)ethoxy)ethyl)carbamoyl)benzoyl)benzoic acid, Probe building block

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About This Item

Empirical Formula (Hill Notation):
C37H33NO9
Molecular Weight:
635.66
UNSPSC Code:
12352200
NACRES:
NA.22

form

powder or crystals

Quality Level

100

reaction suitability

reaction type: click chemistry

storage temp.

−20°C

Application

Hydroxyl di-benzophenone (PEG)3 alkyne is used for chemical probe synthesis, this trifunctional building block contains two light-activated benzophenones, an alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for dual UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Caution

Light and moisture sensitive(Benzophenone is UV-light activated).

Other Notes

Technology Spotlight: Trifunctional Probe Building Blocks

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900610

Hydroxyl di-benzophenone (PEG)3 alkyne

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900619

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4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid, ≥95%

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2-(Prop-2-yn-1-yloxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzoic acid, ≥95%

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900865

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Articles

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

Trifunctional Probe Building Blocks

In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service