804312

2,2-difluoroethylamine hydrochloride

• Synonym(s): 2,2-difluoro-1-ethanamine hydrochloride
• Empirical Formula (Hill Notation): C₂H₆ClF₂N
• CAS Number: 79667-91-7
• Molecular Weight: 117.53
• MDL number: MFCD04038283
• UNSPSC Code: 12352116
• PubChem Substance ID: 329768860
• NACRES: NA.22

Properties

• assay: 95%
• Quality Level: 100
• form: powder
• mp: 132-137 °C (w/decomp)
• storage temp.: 2-8°C
• SMILES string: Cl.NCC(F)F
• InChI: 1S/C2H5F2N.ClH/c3-2(4)1-5;/h2H,1,5H2;1H
• InChI key: YSVKPVHTHFECBE-UHFFFAOYSA-N

Description

Application

2,2-Difluoroethylamine hydrochloride was recently reported to be used as a precursor for the "elusive" difluoromethyl diazomethane species (CF₂HCHN₂). The difluoromethyl diazomethane intermediate can be generated in situ in the presence of tert-butyl nitrite and a catalytic amount of acetic acid.

Other Notes

In Situ Generation of Difluoromethyl Diazomethane for[3+2] Cycloadditions with Alkynes

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable