189901

Methylmagnesium chloride solution

3.0 M in THF

• Synonym(s): Chloromethylmagnesium, Methyl magnesium chloride, Methylmagnesiumchloride
• Linear Formula: CH₃MgCl
• CAS Number: 676-58-4
• Molecular Weight: 74.79
• Beilstein/REAXYS Number: 3587199
• MDL number: MFCD00000468
• UNSPSC Code: 12352103
• PubChem Substance ID: 24851404
• NACRES: NA.22

Properties

• form: liquid
• Quality Level: 200
• autoignition temp.: 609 °F
• reaction suitability: reaction type: Grignard Reaction
• concentration: 3.0 M in THF
• density: 1.013 g/mL at 25 °C
• SMILES string: C[Mg]Cl
• InChI: 1S/CH3.ClH.Mg/h1H3;1H;/q;;+1/p-1
• InChI key: RQNMYNYHBQQZSP-UHFFFAOYSA-M

Description

Application

Methylmagnesium chloride solution (3 M in THF) undergoes 1,3-addition with dialdose derived nitrones to form N-benzylhydroxylamines. The reductive cleavage of the N-O bond of these N-benzylhydroxylamines results in N-benzylaminosugars, which are key moieties of bioactive compounds. It can also react with Garner type aldehydes to form the corresponding secondary alcohols.

Packaging

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

View returnable container options.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Safety Information

• pictograms: GHS02,GHS08,GHS05,GHS07
• signalword: Danger
• hcodes: H225,H260,H314,H335,H336,H351
• pcodes: P210 - P231 + P232 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3 - Water-react 1
• target_organs: Central nervous system, Respiratory system
• supp_hazards: EUH014,EUH019
• Storage Class: 4.3 - Hazardous materials which set free flammable gases upon contact with water
• wgk_germany: WGK 1
• flash_point_f: 1.0 °F - closed cup
• flash_point_c: -17.2 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter