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W387509

Sigma-Aldrich

Dimethyl sulfoxide

≥99%

Synonym(s):
DMSO
Linear Formula:
(CH3)2SO
CAS Number:
Molecular Weight:
78.13
FEMA Number:
3875
Beilstein:
506008
EC Number:
MDL number:
PubChem Substance ID:
Flavis number:
12.175

biological source

synthetic

grade

Halal

Agency

meets purity specifications of JECFA

vapor density

2.7 (vs air)

vapor pressure

0.42 mmHg ( 20 °C)

assay

≥99%

autoignition temp.

573 °F

shelf life

Expiration date period - 5 years

expl. lim.

42 %, 63 °F

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)
189 °C

mp

16-19 °C (lit.)

solubility

water: miscible

density

1.10 g/mL (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

Organoleptic

butter; sulfurous

SMILES string

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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General description

Dimethyl sulfoxide (DMSO) is a hygroscopic, high polarity amphiphilic solvent with an ability to dissolve many compounds. Cytotoxic study of DMSO on the pulp tissue repair-related activity of odontoblast-like cells showed it produced minor effects. Along with phosphorus pentaoxide it participates in the oxidation of carbohydrates to afford aldosuloses and aldosiduloses. DMSO participates in the oxidation of some partially-acetylated carbohydrates followed by elimination to afford unsaturated, derivatives. Solubility of amylose and amylopectin in DMSO has been evaluated.

Application

DMSO has been used to prepare the DMSO-phosphate buffer solution, which was used to dissolve the selective ETB (ET = endothelin) receptor antagonist in a study. It has been used for the preparation of nysatin solution.
Dimethyl sulfoxide may be used in the synthesis of the following:
  • α, β−Unsaturated carbonyl sugar derivatives.
  • Conversion of secondary bromides or olefins to bromohydrin.
  • Synthesis of α-hydroxycarbonyls from corresponding ketones.

Caution

Supercools easily and remelts slowly at room temperature. Solidified product can be re-liquified by warming to room temperature without detriment to the product.

Certificate of Analysis

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Certificate of Origin

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