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一般說明
Tetanus toxin C fragment (TTC) is a non-toxic peptide, which is transported from peripheral axons into spinal motoneurons. It provides protection for motoneurons (MN) in the spinal cord in vivo. TTC regulates membrane binding, internalization and retrograde transport within MN. It initiates neurotrophin-regulated signaling pathways in a Trk receptor-dependent manner. TTC has neuroprotective property in primary cerebellar granule cell culture.
應用
The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin.
The C terminal binding portion of tetanus toxin is not toxic but is taken up by pre-synaptic nerve terminals and exhibits trans-synaptic retrograde transport in central neurons similar to that of tetanus toxin. It is used to map neuronal connections and to target proteins to neurons.
生化／生理作用
Tetanus toxin is a neurotoxin that comprises of a heavy and a light chain linked by disulfide bridges. This neurotoxin enters the cytoplasm and releases the light chain component that subsequently inhibits the release of neurotransmitters2. Studies have reported that the fragment C of tetanus toxin retains most of the determinants that interact with thyroid membranes, gangliosides and neural membranes3.
重構
Each vial, when reconstituted with 50 μl of sterile distilled water, contains 10 μg of tetanus toxin C-fragment in 0.01 M sodium phosphate, pH 7.5. To aid recovery, 0.1% albumin may be added.
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1
標靶器官
Central nervous system
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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T B Helting et al.
The Journal of biological chemistry, 252(1), 187-193 (1977-01-10)
Tetanus toxin was digested with papain, yielding one major polypeptide (Fragment C) with a molecular weight corresponding to 47,000 +/- 5%, thus comprising about one-third of the toxin molecule. Fragment C was antigenically active, atoxic, and stimulated the formation of
Tetanus toxin C-fragment protects against excitotoxic spinal motoneuron degeneration in vivo
Netzahualcoyotzi C and Tapia R
Scientific Reports, 8(1), 16584-16584 (2018)
Interaction of fragments B and C of tetanus toxin with neural and thyroid membranes and with gangliosides.
N P Morris et al.
The Journal of biological chemistry, 255(13), 6071-6076 (1980-07-10)
E Link et al.
Biochemical and biophysical research communications, 189(2), 1017-1023 (1992-12-15)
Tetanus toxin is a potent neurotoxin that inhibits the release of neurotransmitters from presynaptic nerve endings. The mature toxin is composed of a heavy and a light chain that are linked via a disulfide bridge. After entry of tetanus toxin
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