582243

Tetanus Toxin, Clostridium tetani

Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 形狀: lyophilized
• 製造商／商標名: Calbiochem^®
• 存貨情形: not available in Canada,
• 儲存條件: OK to freeze
• 儲存溫度: 2-8°C

描述

一般說明

Produced by the anaerobic bacillus Clostridium tetani. Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.

Produced by the anaerobic bacillus Clostridium tetani, Tetanus toxin is one of the deadliest toxins known. Composed of two polypeptide chains joined by a single interchain disulfide bond. The heavy chain (~100 kDa) participates in binding to the nerve terminals, internalization, retrograde axonal transport, and membrane translocation of the light chain (~50 kDa) into the neuronal cytosol. The light chain inhibits neurotransmitter release after reduction of the disulfide bridge.

Tetanus toxin is produced by Clostridium tetani. Composed of a 100 kDa heavy and a 50 kDa light chain joined by a single interchain disulfide bond.

生化／生理作用

Binds G_T1b ganglioside in a hemagglutination assay

Primary Target
Tetanus toxin is one of the deadliest toxins known

Product does not compete with ATP.

警告

Toxicity: Highly Toxic (H)

重構

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Please refer to the vial label for lot-specific reconstitution volume.

分析報告

Single band by SDS-PAGE

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Montecucco, C., et al. 1994. FEBS Lett. 346, 92.
Wellhöner, H.H., et al. 1987. J. Biol. Chem. 262, 17374.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300 + H330,H370
• 防範說明: P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310
• 危險分類: Acute Tox. 1 Oral - Acute Tox. 2 Inhalation - STOT SE 1
• 標靶器官: Central nervous system
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3