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Key Documents

D0564

Sigma-Aldrich

Diphtheria Toxin

from Corynebacterium diphtheriae, ≥98% (SDS-PAGE), lyophilized powder, protein synthesis inhibitor

同義詞:

DTx

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About This Item

MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

白喉毒素 来源于白喉杆菌, lyophilized powder, Product is in unnicked form

品質等級

形狀

lyophilized powder

儲存溫度

2-8°C

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一般說明

白喉毒素可用作细胞特异性细胞毒性免疫毒素中的毒素成分。具有天然内体逃逸机制的细菌毒素易位结构域已被用于开发有效的非病毒载体用于基因治疗。

應用

白喉棒状杆菌的白喉毒素已用于:


  • 小胶质细胞耗竭,研究小鼠创伤后应激障碍
  • 腹腔注射转基因小鼠,以在消融过程中融合移植的造血干细胞和祖细胞(HSPCs)后选择杂交种
  • 研究其对嗜酸性粒细胞缺陷小鼠株(iPHIL)中嗜酸性粒细胞系祖细胞的影响

生化/生理作用

白喉毒素是一种由白喉棒状杆菌产生的细菌毒素。它包含三个具有细胞内作用的结构域。这些结构域参与细胞中毒、细胞表面结合和内化为内体、穿过内体膜转运到胞质溶胶并抑制细胞蛋白质合成。白喉毒素可用于构建生物技术工具和治疗方法。它通过催化真核生物中靶蛋白的二磷酸腺苷(ADP)核糖基化来抑制蛋白质合成。

外觀

含Tris和EDTA的冻干粉。

重構

当用无菌蒸馏水将每管重悬至0.5 mL时,0.01 M Tris和0.001 M Na2EDTA,pH 7.5中含有~1 mg的白喉毒素。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

S M Yellon et al.
Biology of reproduction, 100(5), 1386-1394 (2019-01-11)
To test the hypothesis that macrophages are essential for remodeling the cervix in preparation for birth, pregnant homozygous CD11b-dtr mice were injected with diphtheria toxin (DT) on days 14 and 16 postbreeding. On day 15 postbreeding, macrophages (F4/80+) were depleted
Biology and molecular epidemiology of diphtheria toxin and the tox gene
The Journal of Infectious Diseases, 181 (2000)
Mary F Fontana et al.
PLoS pathogens, 12(12), e1006046-e1006046 (2016-12-07)
Dynamic regulation of leukocyte population size and activation state is crucial for an effective immune response. In malaria, Plasmodium parasites elicit robust host expansion of macrophages and monocytes, but the underlying mechanisms remain unclear. Here we show that myeloid expansion
Benjamin J Vakoc et al.
Nature medicine, 15(10), 1219-1223 (2009-09-15)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous contrast agents that enable multiphoton microscopy, however, limit the ability
Vicky A Tobin et al.
Nature, 464(7287), 413-417 (2010-02-26)
Many peptides, when released as chemical messengers within the brain, have powerful influences on complex behaviours. Most strikingly, vasopressin and oxytocin, once thought of as circulating hormones whose actions were confined to peripheral organs, are now known to be released

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