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About This Item
經驗公式（希爾表示法）:
C29H46N2O3S
CAS號碼:
分子量：:
502.75
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
顏色
white
溶解度
DMSO: soluble 16 mg/mL
H2O: insoluble
SMILES 字串
CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(O)=O
InChI
1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)
InChI 密鑰
PKNYXWMTHFMHKD-UHFFFAOYSA-N
基因資訊
human ... PPARA(5465)
應用
GW7647已被用作过氧化物酶体增殖物激活受体α (PPAR α)配体：
- 脱脂培养基，用于治疗原代人肝细胞
- 测试对心肌细胞糖酵解功能的影响
- 测试对幼鼠心脏的影响
- 在乳腺癌MDA-MB-231细胞中激活PPAR
生化／生理作用
GW7647可降低血清甘油三酯水平，提高β-氧化相关基因的肝脏表达。GW7647与二甲双胍联合应用可提高肝脏脂肪变性或损伤情况下血清中天冬氨酸转氨酶(AST)和丙氨酸转氨酶(ALT)的水平。
强效人PPARα激动剂。用于研究人细胞中PPARα受体的生物学。
法律資訊
根据GlaxoSmithKline协议，仅为研究目的出售
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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