全部照片(3)
About This Item
線性公式:
C18H19N3O3S
CAS號碼:
分子量：:
357.43
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
溶解度
DMSO: ≥10 mg/mL
起源
GlaxoSmithKline
儲存溫度
2-8°C
SMILES 字串
CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3
InChI
1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
InChI 密鑰
YASAKCUCGLMORW-UHFFFAOYSA-N
基因資訊
human ... PPARG(5468)
尋找類似的產品？ 前往 產品比較指南
一般說明
Rosiglitazone is a member of the thiazolidinedione family. It effectively lowers glucose levels by enhancing the response of target cells to insulin, without causing increased stimulation and release of insulin by the pancreatic beta cells. Rosiglitazone functions by activating the nuclear peroxisome proliferator-activated (PPAR) receptor gamma, which plays a key role in regulating adipogenesis, glucose metabolism, and genetic networks. It exhibits high potency as a thiazolidinedione, with a binding affinity for PPAR-gamma that is 30-fold higher than pioglitazone. Furthermore, it increases insulin-stimulated IRS-1/2 in skeletal muscle and adipose tissue, leading to the expression of the GLUT4 glucose transporter.
應用
罗格列酮已被用于：
- 脂肪细胞分化的培养基成分
- 人结肠癌细胞的细胞增殖测定
- 脂肪细胞中Bcl-2样蛋白13（Bcl2113）的表达
- 作为过氧化物酶体增殖物激活受体γ（PPARγ）的配体
生化／生理作用
罗格列酮是PPARγ的强效激动剂，对人受体的EC50为43 nM。 它是一种抗糖尿病药，作为胰岛素增敏剂，可与脂肪细胞的PPARγ受体结合并使细胞对胰岛素更敏感。
特點和優勢
该化合物是ADME Tox和基因调控研究的特色产品。发现更多 ADME Tox 和 基因调控 特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
A novel role for Bcl2l13 in promoting beige adipocyte biogenesis
Ju L, et al.
Biochemical and Biophysical Research Communications, 506(3), 485-491 (2018)
Jérôme Carayol et al.
Nature communications, 8(1), 2084-2084 (2017-12-14)
Thousands of genetic variants have been associated with complex traits through genome-wide association studies. However, the functional variants or mechanistic consequences remain elusive. Intermediate traits such as gene expression or protein levels are good proxies of the metabolic state of
Rosiglitazone diminishes the high-glucose-induced modulation of 5-fluorouracil cytotoxicity in colorectal cancer cells
Lau MF, et al.
EXCLI Journal, 17, 186-186 (2018)
Siyu Xie et al.
Nutrients, 11(7) (2019-07-22)
Promoting white-to-beige adipocyte transition is a promising approach for obesity treatment. Although Liensinine (Lie), a kind of isoquinoline alkaloid, has been reported to affect white-to-beige adipocyte transition, its effects on inhibiting beige adipocytes recovering to white adipocytes and maintaining the
María Isabel Cuartero et al.
Stroke, 44(12), 3498-3508 (2013-10-19)
Neutrophils have been traditionally recognized as major mediators of a deleterious inflammatory response in acute ischemic stroke, but their potential as a therapeutic target remains unexplored. Recent evidence indicates that neutrophils may acquire different phenotypes and contribute to resolution of
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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