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F3055

Sigma-Aldrich

夫拉平度 盐酸盐

≥98% (HPLC), powder

同義詞:

(−)-2-（2-氯苯基）-5,7-二羟基-8-[(3 S ,4 R )-3-羟基-1-甲基-4-哌啶基]-4 H -1-苯并吡喃-4-酮 盐酸盐, L-86-8276, NSC-649890

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About This Item

經驗公式（希爾表示法）:
C21H20ClNO5 ·HCl · xH2O
CAS號碼:
131740-09-5
分子量：:
438.30 (anhydrous basis)
MDL號碼:
MFCD26792554
分類程式碼代碼:
12352200
PubChem物質ID:
24724481
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to light brown

溶解度

H2O: ~2 mg/mL
DMSO: >5 mg/mL

儲存溫度

2-8°C

SMILES 字串

OC1=C(C(C=C(C2=C(Cl)C=CC=C2)O3)=O)C3=C([C@H]4CCN(C)C[C@H]4O)C(O)=C1.Cl

InChI

1S/C21H20ClNO5.ClH/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3;1H/t12-,17+;/m0./s1

InChI 密鑰

LGMSNQNWOCSPIK-LWHGMNCYSA-N

基因資訊

human ... CDK1(983) , CDK2(1017) , CDK4(1019) , CDK6(1021) , CDK7(1022) , CDK9(1025)

應用

夫拉平度盐酸盐已：
  • 用作周期蛋白依赖性激酶9 (CDK9)抑制剂，以研究其对猪胚胎成纤维细胞组蛋白H3赖氨酸36位点甲基化(H3K36)和转录失活的影响
  • 用作RNA聚合酶抑制剂，以研究其对肝细胞的影响
  • 用作RNA转录抑制剂，以研究其对斑马鱼胚胎常染色质粗化的影响

生化／生理作用

盐酸 Flavopiridol 是一种强效的 CDK（细胞周期蛋白依赖性激酶）和 CDC25 磷酸酶家族抑制剂。
黄烷醇是一种从双花叶姜中提取的半合成黄酮类化合物，作为抗肿瘤剂可对抗几种癌症。它还显示出抗癌特性，因此，它已被研究用于治疗急性髓系白血病(AML)。

特點和優勢

《受体分类和信号转导》手册的 CDK 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析證明 (COA)

Lot/Batch Number
116M4755V
035M4737V
042M4718V
100M4723
019K46111

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Stefano de Pretis et al.
Genome research, 27(10), 1658-1664 (2017-09-15)
Overexpression of the MYC transcription factor causes its widespread interaction with regulatory elements in the genome but leads to the up- and down-regulation of discrete sets of genes. The molecular determinants of these selective transcriptional responses remain elusive. Here, we
Uma Raju et al.
Cancer research, 63(12), 3263-3267 (2003-06-18)
Flavopiridol, a cyclin-dependent kinase (cdk) inhibitor, can cause cell cycle arrest, induce apoptosis in cancer cells, and inhibit tumor cell growth in vivo. The present study investigated the in vitro radiosensitizing effect of flavopiridol and the underlying molecular mechanisms in
Saowaluk Saisomboon et al.
Heliyon, 5(5), e01675-e01675 (2019-06-14)
Flavopiridol, a pan-cyclin-dependent kinase (CDK) inhibitor, was recently identified as an effective antitumor agent for several cancers. We investigated the antitumor effect of flavopiridol on cholangiocarcinoma (CCA), in vitro and in vivo. A methylthiotetrazole assay revealed that the proliferation of
Anne Pumfery et al.
Current pharmaceutical design, 12(16), 1949-1961 (2006-06-22)
Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II transcription. Several pharmacological CDK inhibitors (PCIs) are currently in clinical trials as potential cancer therapeutics since CDK hyperactivation is detected in the majority of neoplasias. Within
Nazia Abbasi et al.
Life science alliance, 3(10) (2020-08-21)
Tumorigenesis in different segments of the intestinal tract involves tissue-specific oncogenic drivers. In the colon, complement component 3 (C3) activation is a major contributor to inflammation and malignancies. By contrast, tumorigenesis in the small intestine involves fatty acid-binding protein 1
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