S4400

Staurosporine

from Streptomyces sp., ≥98% (HPLC), film, protein kinase inhibitor

• 同義詞: Staurosporine, Antibiotic AM-2282
• 經驗公式（希爾表示法）: C₂₈H₂₆N₄O₃
• CAS號碼: 62996-74-1
• 分子量：: 466.53
• Beilstein: 1060573
• MDL號碼: MFCD00077402
• 分類程式碼代碼: 12161501
• PubChem物質ID: 57654618
• NACRES: NA.77

屬性

• product name: Staurosporine from Streptomyces sp., ≥98% (HPLC), film
• 生物源: Streptomyces sp.
• 品質等級: 300
• 化驗: ≥98% (HPLC)
• 形狀: film
• mp: 288-291 °C
• 溶解度: DMSO: soluble; H₂O: insoluble; ethanol: soluble; methanol: soluble
• 抗生素活性譜: neoplastics
• 作用方式: enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
• InChI 密鑰: HKSZLNNOFSGOKW-ZGQXJOJZSA-N

描述

一般說明

Chemical structure: indol derivative

Staurosporinefrom Streptomyces sp. is an alkaloid that induces apoptosis in a rangeof cell lines. It facilitates the inhibition of tumor cell proliferation, PKCinhibition, and blockage of cell cycle progression in various cells. Themechanisms followed by staurosporine-induced apoptosis differ among differentcell lines that include, mitochondrial apoptotic pathway, Bcl-2 overexpession,and caspase-independent mechanisms. It partially reverses multi-drug resistance (MDR), sensitizing cellswith MDR phenotype to cytotoxic agents. Staurosporine inhibits p-glycoprotein(Pgp) phosphorylation. However, the functional significance of Pgpphosphorylation is ill-defined.

應用

Staurosporine from Streptomyces sp. was used to induce cell death in human mesenchymal stem cells and to induce cell death by PKC inhibition in hamster lung fibroblast line CCL-39.

生化／生理作用

Staurosporine from Streptomyces sp. yields clear, colorless to faint yellow solution in methanol at 2 mg/ml.

Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the CDKs and InsR pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全資訊

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H340,H350,H361d,H413
• 防範說明: P202 - P273 - P280 - P308 + P313 - P405 - P501
• 危險分類: Aquatic Chronic 4 - Carc. 1B - Muta. 1B - Repr. 2
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges