8.51088

TOTU

Novabiochem^®

• 同義詞: TOTU, O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,NÆ,NÆ-tetramethyluronium tetrafluoroborate
• 經驗公式（希爾表示法）: C₁₀H₁₇BF₄N₄O₃
• CAS號碼: 136849-72-4
• 分子量：: 328.07
• MDL號碼: MFCD00192127
• 分類程式碼代碼: 12352116
• NACRES: NA.22

屬性

• 品質等級: 200
• 產品線: Novabiochem^®
• 化驗: ≥99.0% (HPLC)
• 形狀: powder
• 效力: 500-650 mg/kg LD₅₀, oral (Rat)
• 反應適用性: reaction type: Coupling Reactions
• 製造商／商標名: Novabiochem^®
• mp: 142-148 °C
• 應用: peptide synthesis
• 儲存溫度: 2-8°C
• SMILES 字串: [B-](F)(F)(F)F.N([C+](N(C)C)ON=C(C(=O)OCC)C#N)(C)C
• InChI: 1S/C10H17N4O3.BF4/c1-6-16-9(15)8(7-11)12-17-10(13(2)3)14(4)5;2-1(3,4)5/h6H2,1-5H3;/q+1;-1
• InChI 密鑰: FPQVGDGSRVMNMR-UHFFFAOYSA-N

描述

一般說明

TOTU is an excellent alternative to HOBt-based coupling reagents such as HBTU and TBTU. It has high reactivity and is likely to have low allergenicity and low explosivity. The by-products of using this coupling reagent are water-soluble, making it an ideal choice for solution phase coupling reactions.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents


Literature references

^[1] G. Breipohl & W. Koenig, US patent 5166394.

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clear soluble

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H302 - H317 - H318 - H335
• 防範說明: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1A - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable