8.51008

TBTU

≥98.0% (HPLC), for peptide synthesis, Novabiochem^®

• 同義詞: TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate
• 經驗公式（希爾表示法）: C₁₁H₁₆BF₄N₅O
• CAS號碼: 125700-67-6
• 分子量：: 321.08
• MDL號碼: MFCD00077413
• 分類程式碼代碼: 12352107
• 酶委員會索引編號: 423-040-4
• NACRES: NA.22

屬性

• product name: TBTU, 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethylaminium tetrafluoroborate Novabiochem^®
• 品質等級: 200
• 產品線: Novabiochem^®
• 化驗: ≥98.0% (HPLC)
• 形狀: powder
• 反應適用性: reaction type: Coupling Reactions
• 製造商／商標名: Novabiochem^®
• mp: 195-199 °C (decomposes)
• 應用: peptide synthesis
• 儲存溫度: 15-25°C
• InChI: 1S/C11H16N5O.B.4FH/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;;;;;/h5-8H,1-4H3;;4*1H/q+1;+3;;;;/p-4
• InChI 密鑰: SHGLJDNRZIDILW-UHFFFAOYSA-J

描述

一般說明

See entry for HBTU (851006). TBTU has been employed to generate 1,2,4-oxadiazoles from carboxylic acids ^[1].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. F. Poulain, et al. (2001) Tetrahedron Lett., 42, 1495.

應用

• Synthesis of phospho-urodilatin by combination of global phosphorylation with the segment coupling approach.: This research focuses on the synthesis of phospho-urodilatin, demonstrating the effectiveness of TBTU as a coupling reagent in segment coupling strategies for peptide synthesis (Mostafavi et al., 1996).


• Effect of tertiary amine on the carbodiimide-mediated peptide synthesis.: The study investigates the impact of tertiary amines on carbodiimide-mediated peptide synthesis, highlighting the role of TBTU in enhancing peptide coupling efficiency (Beyermann et al., 1991).

聯結

Replaces: 01-62-0015

分析報告

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Loss on drying: ≤ 0.5 %
Water (K. F.): ≤ 0.5 %

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS07
• 訊號詞: Danger
• 危險聲明: H228 - H317
• 防範說明: P210 - P240 - P241 - P261 - P280 - P302 + P352
• 危險分類: Flam. Sol. 1 - Skin Sens. 1A
• 儲存類別代碼: 4.1A - Other explosive hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable