8.51087

PyClock

6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate Novabiochem^®

• 同義詞: PyClock, 6-Chloro-benzotriazole-1-yloxy-tris-pyrrolidinophosphonium hexafluorophosphate
• 經驗公式（希爾表示法）: C₁₈H₂₇ClF₆N₆OP₂
• CAS號碼: 893413-42-8
• 分子量：: 554.84
• MDL號碼: MFCD14560589
• 分類程式碼代碼: 12352107
• NACRES: NA.22

屬性

• 品質等級: 200
• 產品線: Novabiochem^®
• 化驗: ≥98.0% (HPLC)
• 形狀: powder
• 反應適用性: reaction type: Coupling Reactions
• 製造商／商標名: Novabiochem^®
• mp: 165-175 °C
• 應用: peptide synthesis
• 儲存溫度: 2-8°C
• SMILES 字串: F[P-](F)(F)(F)(F)F.[P+](N5CCCC5)(N4CCCC4)(N3CCCC3)O[n]1nnc2c1cc(cc2)Cl
• InChI: 1S/C18H27ClN6OP.F6P/c19-16-7-8-17-18(15-16)25(21-20-17)26-27(22-9-1-2-10-22,23-11-3-4-12-23)24-13-5-6-14-24;1-7(2,3,4,5)6/h7-8,15H,1-6,9-14H2;/q+1;-1
• InChI 密鑰: QJZCQEPNBRAYQL-UHFFFAOYSA-N

描述

一般說明

PyClocK is the 6-chloro analog of PyBOP. Reaction of protected amino acids with PyClocK in the presence of base generates the corresponding 6-chloro-1-benzotriazolyl (Cl-OBt) ester. These active esters are considerably more reactive than those produced when using PyBOP or HBTU, owing to 6-chloro-1-hydroxybenzotriazole (Cl-HOBt) being more acidic than HOBt. PyClocK is an excellent coupling reagent for situations where carboxyl activation may be sluggish, such as cyclizations and fragment condensations, as unlike imminium-based reagents such as HBTU and HATU excess PyClocK cannot cause end-capping of peptide chains.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): conforms
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (5% in NMP (1-Methyl-2-pyrrolidone)): clear

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315 - H319 - H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable