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A2942

Sigma-Aldrich

Amphotericin B

solution, suitable for cell culture, BioReagent

别名:

Amphotericin, Fungizone

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About This Item

经验公式（希尔记法）:
C47H73NO17
CAS号:
1397-89-3
分子量:
924.08
MDL號碼:
MFCD00877763
分類程式碼代碼:
12352207
PubChem物質ID:
24890711
NACRES:
NA.76

product name

两性霉素 B 溶液, 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture

品質等級

200

無菌

0.1 μm filtered

產品線

BioReagent

形狀

liquid

濃度

250 μg/mL in deionized water

技術

cell culture | mammalian: suitable

顏色

yellow

抗生素活性譜

fungi
yeast

作用方式

cell membrane | interferes

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(=O)O[Na])O2

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI 密鑰

APKFDSVGJQXUKY-INPOYWNPSA-N

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相关类别

一般說明

两性霉素B是一种大环内酯，具有亲水性多羟基链和亲脂性多烯烃链。

應用

两性霉素B溶液已被用于：
  • 作为腹腔注射剂用于治疗烟曲霉感染小鼠
  • 作为中国美利奴绵羊卵巢培养的理想培养基的组成部分
  • 在收集马黄体时用作运输培养基中的组成成分
  • 作为RPMI培养基中的补充剂，用于培养小鼠-小鼠B细胞杂交瘤55-6细胞系

生化／生理作用

两性霉素B对真菌和酵母最有效。它通过结合与膜相关的固醇而形成跨膜通道，从而导致小分子的泄漏。尽管两性霉素B是治疗真菌病的有效抗生素，它会引起毒性。
两性霉素B是一种来自链霉菌的多烯抗真菌抗生素，临床上用于治疗系统性真菌感染。它对真菌和细菌细胞膜的固醇，尤其是麦角固醇具有很高的亲和力。 维持抗真菌细胞培养的正常用量为2.5 mg/L，同时在培养基中使用青霉素和链霉素。

包裝

20、50、100 ml

成分

该产品以250 μg/mL溶于去离子水中的两性霉素B提供。它是一种含有两性霉素B和以下提高其溶解度的组分组成的溶液：脱氧胆酸钠、氯化钠和磷酸钠。

注意

两性霉素B在37°C的培养条件下可保持活性3天。

準備報告

其在水溶液中形成沉淀是正常现象。 对溶液进行混合可重新溶解大部分沉淀物，但是，如果无法完全溶解，两性霉素B仍然适合使用。

其他說明

保存于密闭容器内，置于干燥通风处。光敏感。

也與該產品經常一起購買

产品编号
说明
价格

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Yong-Hong Wang et al.
The Journal of antibiotics, 63(9), 553-557 (2010-07-08)
A new derivative of amphotericin B named amphotericin B(5) has been obtained under the following condition: amphotericin B powder was first dissolved in N,N-dimethylformamide at room temperature to obtain a solution of concentration of 2.0 mg ml(-1). Then, the solution
María Lourdes Acosta et al.
Cytotechnology, 54(3), 189-200 (2008-11-13)
Batch cultures were carried out to study the kinetic, stoichiometry, and regulation of glucose and glutamine metabolism of a murine hybridoma line. Asymmetric logistic equations (ALEs) were used to fit total and viable cell density, and nutrient and metabolite/product concentrations.
J Bolard et al.
Biochemistry, 30(23), 5707-5715 (1991-06-11)
The inducement of K+ permeability through membranes by the polyene antibiotic amphotericin B (AmB) has been analyzed as a measure of the antibiotic activity. Dose-response curves have been obtained with cholesterol- and ergosterol-containing egg yolk phosphatidylcholine large unilamellar vesicles (LUVs)
Luigina Romani et al.
Blood, 103(11), 4232-4239 (2004-02-26)
Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha 1, a naturally occurring thymic peptide, induces functional maturation and interleukin-12
Naira Caroline Godoy Pieri et al.
Stem cell research & therapy, 10(1), 135-135 (2019-05-22)
Xenotransplantation of spermatogonial stem cells (SSCs) has become a popular topic in various research fields because manipulating these cells can provide insights into the mechanisms associated with germ cell lines and the entire spermatogenesis process; moreover, these cells can be
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