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A9528

Sigma-Aldrich

两性霉素B，可溶

powder, suitable for cell culture, BioXtra

别名:

两性霉素B 来源于链霉菌 属, Fungizone

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About This Item

经验公式（希尔记法）:
C47H73NO17
CAS号:
1397-89-3
分子量:
924.08
Beilstein:
78342
MDL號碼:
MFCD00877763
分類程式碼代碼:
12352207
eCl@ss:
34010400
PubChem物質ID:
24891468
NACRES:
NA.76

product name

两性霉素B，可溶, powder, γ-irradiated, BioXtra, suitable for cell culture

品質等級

300

無菌

γ-irradiated

產品線

BioXtra

形狀

powder

技術

cell culture | mammalian: suitable

抗生素活性譜

fungi
yeast

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI 密鑰

APKFDSVGJQXUKY-INPOYWNPSA-N

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相关类别

一般說明

化学结构：多烯

應用

两性霉素B是来自链霉菌属的一种多烯抗真菌抗生素。它对真菌和细菌细胞膜的固醇，尤其是麦角固醇具有很高的亲和力。 维持抗真菌细胞培养的正常用量为2.5 mg/L，同时在培养基中使用青霉素和链霉素。

生化／生理作用

两性霉素B可与甾醇结合，在膜中形成孔，并导致小分子的泄漏。该产品对真菌和酵母最有效。

包裝

可溶性两性霉素B包装在琥珀色玻璃瓶中，内容物置于插入的熔锥内。

成分

本品为两性霉素 B 的胶体混悬液，以去氧胆酸盐为增溶剂。 处方为约 45% 两性霉素 B 和 35% 脱氧胆酸钠的磷酸钠和氯化钠溶液。

注意

两性霉素 B 在 37°C 培养 3 天仍保持活性。在-20°C 条件下，通过防风避光，本品可保持活性 5 年。

準備報告

两性霉素 B 可溶于水 (19.6-20.4 mg/mL)，在自然 pH 下，无需加热，即可得到淡黄色澄清至轻微浑浊的溶液。
水溶液由于溶解性差，不能过滤除菌。 如果在无菌水中复溶，则无需过滤除菌。

也可溶于 DMSO (30-40 mg/mL) 和二甲基甲酰胺 (2-4 mg/mL)。

其他說明

保存于密闭容器内，置于干燥通风处。本品对光和湿度敏感。置于干燥处保存。
根据 UV 纯度计算包装产品的实际固体重量。

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仅试剂盒组分

产品编号
说明
  • Amphotericin B ~ 45 %
  • Sodium deoxycholate ~ 35 %
  • Sodium phosphate balance

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H372

危險分類

STOT RE 1

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Fungal infections in lamellar keratoplasty are a growing concern. Optisol-GS does not contain an antifungal agent and supplementation with 0.255 μg/mL Amphotericin B (AmpB) has been considered. This study tested the ability of 0.255 μg/mL AmpB in Optisol-GS to eliminate
Moises A Huaman et al.
Frontiers in immunology, 11, 607957-607957 (2021-01-05)
Tuberculosis has been associated with increased risk of atherosclerotic cardiovascular disease. To examine whether mycobacterial infection exacerbates atherosclerosis development in experimental conditions, we infected low-density lipoprotein receptor knockout (Ldlr -/-) mice with Mycobacterium bovis Bacille-Calmette-Guérin (BCG), an attenuated strain of
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Calcium signals are initiated in immune cells by the process of store-operated calcium entry (SOCE), where receptor activation triggers transient calcium release from the endoplasmic reticulum, followed by opening of plasma-membrane calcium-release activated calcium (CRAC) channels. ORAI1, ORAI2, and ORAI3
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Action potentials are thought to be determinant for the induction of long-term synaptic plasticity, the cellular basis of learning and memory. However, neuronal activity does not lead systematically to an action potential but also, in many cases, to synaptic depolarizing
Malav S Trivedi et al.
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Dietary interventions like gluten-free and casein-free diets have been reported to improve intestinal, autoimmune and neurological symptoms in patients with a variety of conditions; however, the underlying mechanism of benefit for such diets remains unclear. Epigenetic programming, including CpG methylation
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