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G1397

Sigma-Aldrich

Gentamicin

liquid, non-animal origin, suitable for cell culture, BioReagent

别名:

Gentamicin

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About This Item

CAS号:
1405-41-0
MDL號碼:
MFCD00270181
分類程式碼代碼:
12352207
eCl@ss:
42020823
PubChem物質ID:
329799839
NACRES:
NA.76

product name

庆大霉素 溶液, 50 mg/mL in deionized water, liquid, 0.1 μm filtered, BioReagent, suitable for cell culture

生物源

microbial

品質等級

300

無菌

0.1 μm filtered

產品線

BioReagent

形狀

liquid

效力

50-60 mg per mL

濃度

50 mg/mL in deionized water

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

顏色

colorless to light yellow

密度

1.000 g/cm3

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@@H](CC[C@H]6N)[C@@H](C)N)[C@@H]5O.CN[C@H](C)[C@@H]7CC[C@@H](N)[C@H](O7)O[C@@H]8[C@@H](N)C[C@@H](N)[C@H](O[C@H]9OC[C@](C)(O)[C@H](NC)[C@H]9O)[C@H]8O

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI 密鑰

RDEIXVOBVLKYNT-HDZPSJEVSA-N

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一般說明

Gentamicin, also known as gentiomycin C, is an aminoglycoside, which is naturally produced by Gram-negative bacteria. This antibiotic functions by preventing protein synthesis. Gentamicin sulfate prevents the growth of both Gram positive and Gram negative bacteria, in vivo and in vitro. In tissue culture, gentamicin sulfate is used to inhibit the growth of various strains of mycoplasma.

應用

Gentamicin solution has been used as an antibiotic component in eukaryotic cell culture and bacterial culture.
Gentamicin sulfate is a broad-spectrum antibiotic used as a selection agent (gentamicin-resistance gene) in molecular biology and cell culture applications. This product is formulated to contain 50 mg/mL Gentamicin in deionized water and is recommended for use in eukaryotic cell culture at a volume of 1 milliliter per liter.
Gentamicin sulfate solution has been used as a component of different types of culture media.

生化／生理作用

Gentamicin is recommended for treating sepsis during emergency treatment. It is an alternate to ceftriaxone for treating genital infection.
作用机制：庆大霉素可通过与核糖体的30S亚基结合来抑制蛋白质合成。

抗菌谱：包括革兰氏阴性和革兰氏阳性细菌，包括对于四环素，氯霉素，卡那霉素和粘菌素，某些特定假单胞菌菌株，变形杆菌属，Staphylococcus 和Streptococcus的抗性。

成分

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.

注意

The product is stable at 37° for 5 days and is stored at 2-8°C.

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H317,H334

危險分類

Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial
Ross JDC, et al.
Lancet, e0210012-e0210012 (2019)
J Cummings et al.
British journal of cancer, 92(3), 532-538 (2005-02-03)
The inhibitor of apoptosis protein, XIAP, is frequently overexpressed in chemoresistant human tumours. An antisense oligonucleotide (AEG 35156/GEM 640) that targets XIAP has recently entered phase I trials in the UK. Method validation data are presented on three pharmacodynamic assays
Improving peak concentrations of a single dose regime of gentamicin in patients with sepsis in the emergency department
Cobussen M, et al.
PLoS ONE, 14(1), e0210012-e0210012 (2019)
Ruochan Chen et al.
Frontiers in immunology, 10, 1904-1904 (2019-08-24)
Inflammasome activation can trigger an inflammatory and innate immune response through the release of cytokines and induction of pyroptosis. A dysfunctional inflammasome has been implicated in the development of human pathologies, including sepsis and septic shock. Here, we show that
David E Swayne
International journal of food microbiology, 108(2), 268-271 (2006-02-17)
A precise, reproducible microassay was developed to measure thermal inactivation of high pathogenicity avian influenza (HPAI) virus in chicken meat. Small pieces of breast or thigh meat (0.05 g) from chickens infected with A/chicken/Pennsylvania/1370/1983 (H5N2) (PA/83) or A/chicken/Korea/ES/2003 (H5N1) (Korea/03)
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