A2411

两性霉素B 来源于链霉菌 属

BioReagent, suitable for cell culture, ~80% (HPLC)

• 别名: Fungizone
• 经验公式（希尔记法）: C₄₇H₇₃NO₁₇
• CAS号: 1397-89-3
• 分子量: 924.08
• Beilstein: 78342
• EC號碼: 215-742-2
• MDL號碼: MFCD00877763
• 分類程式碼代碼: 12352207
• PubChem物質ID: 24890655
• NACRES: NA.76

属性

• 生物源: Streptomyces sp.
• 品質等級: 300
• 產品線: BioReagent
• 化驗: ~80% (HPLC)
• 形狀: solid
• 效力: >750.00 μg per mg (Dry basis)
• 技術: cell culture | mammalian: suitable
• 顏色: yellow to yellow-orange
• 溶解度: H₂O: slightly soluble
• 抗生素活性譜: fungi; yeast
• 作用方式: cell membrane | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
• InChI: 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• InChI 密鑰: APKFDSVGJQXUKY-INPOYWNPSA-N

说明

一般說明

Chemical structure: polyene

應用

Amphotericin B is a polyene antifungal antibiotic from Streptomyce sp. It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium.

生化／生理作用

两性霉素B可与甾醇结合，在膜中形成孔，并导致小分子的泄漏。该产品对真菌和酵母最有效。

注意

Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.

準備報告

Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.

其他說明

Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H372
• 防範說明: P260 - P264 - P270 - P314 - P501
• 危險分類: STOT RE 1
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves