PHR1789

阿霉素 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: DOX, 多柔比星^® 盐酸盐, 羟基柔红霉素 盐酸盐
• 经验公式（希尔记法）: C₂₇H₂₉NO₁₁ · HCl
• CAS号: 25316-40-9
• 分子量: 579.98
• Beilstein: 4229251
• EC號碼: 246-818-3
• MDL號碼: MFCD00077757
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329823614
• NACRES: NA.24

属性

• 等級: certified reference material; pharmaceutical secondary standard
• 品質等級: 300
• agency: traceable to BP 990; traceable to Ph. Eur. D2975000; traceable to USP 1225703
• API 家族: doxorubicin
• 形狀: powder
• CofA: current certificate can be downloaded
• 包裝: pkg of 200 mg
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• mp: 216 °C (dec.) (lit.)
• 應用: pharmaceutical (small molecule)
• 儲存溫度: -10 to -25°C
• SMILES 字串: Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
• InChI 密鑰: MWWSFMDVAYGXBV-RUELKSSGSA-N
• 基因資訊: human ... TOP2A(7153)

说明

一般說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

應用

This pharmaceutical secondary standard can also be used as follows:

• Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples
• Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe₂O₄) modified carbon paste electrode in biological fluid and injection samples
• Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor
• RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations
• Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

腳註

To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

推薦產品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H340,H350,H360FD
• 防範說明: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable