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D8809

Sigma-Aldrich

柔红霉素 盐酸盐

meets USP testing specifications

别名:

道诺霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C27H29NO10 · HCl
CAS号:
23541-50-6
分子量:
563.98
Beilstein:
4229221
EC號碼:
245-723-4
MDL號碼:
MFCD04974507
分類程式碼代碼:
41116107
PubChem物質ID:
24894229
NACRES:
NA.21

agency

USP/NF
meets USP testing specifications

品質等級

200

形狀

solid

抗生素活性譜

neoplastics

作用方式

DNA synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI

1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI 密鑰

GUGHGUXZJWAIAS-QQYBVWGSSA-N

基因資訊

human ... TOP2A(7153)

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相关类别

生化／生理作用

天然荧光蒽环类抗生素、抗癌药。Pgp、MRP-1 和 BCRP 的底物。荧光特性已被运用于测量药物外排泵的活性及解决多种多药耐药蛋白在细胞内定位的重要问题，以及亚细胞器（高尔基体和溶酶体）在药物隔离中及抗药性表型中的作用。柔红霉素根据 pH 分配类型机制被隔离到溶酶体中。 强效 DNA 和 RNA 合成抑制剂。
强效抗癌药。抑制 DNA 和 RNA 合成，作为序列特异性 ds-DNA 嵌入剂。

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBD6119V
WXBD4542V
SLCC6692
SLBX6832
WXBC5749V

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