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Sigma-Aldrich

柔红霉素 盐酸盐

≥90% (HPLC)

别名:

道诺霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C27H29NO10 · HCl
CAS号:
23541-50-6
分子量:
563.98
Beilstein:
4229221
EC號碼:
245-723-4
MDL號碼:
MFCD04974507
分類程式碼代碼:
51102829
PubChem物質ID:
57648441
NACRES:
NA.85

生物源

synthetic

化驗

≥90% (HPLC)

形狀

powder

顏色

red to deep red

抗生素活性譜

neoplastics

作用方式

DNA synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

Cl.COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O

InChI

1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1

InChI 密鑰

GUGHGUXZJWAIAS-QQYBVWGSSA-N

基因資訊

human ... TOP2A(7153)

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一般說明

Chemical structure: aminoglycoside

應用

Daunorubicin hydrochloride is used in photostability, antileukemic, and drug metabolism studies.

生化／生理作用

On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Daunomycin effectively binds to every 3 base pairs which causes unwinding.
强效抗癌药。抑制 DNA 和 RNA 合成，作为序列特异性 ds-DNA 嵌入剂。

包裝

5 mg, 25 mg

其他說明

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas.

象形圖

Skull and crossbonesHealth hazard
GHS06,GHS08

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Carc. 2 - Muta. 2 - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

分析证书(COA)

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Photoprotection of Daunorubicin Hydrochloride with Sodium Sulfite.
Mohammad S. Islam* and Ahmed F. Asker
Journal of Pharmaceutical Sciences, 49, 122-126 (1995)
Kevin W H Yee et al.
Blood, 104(13), 4202-4209 (2004-08-12)
Fetal liver tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutations are the most common molecular abnormality associated with adult acute myeloid leukemia (AML). To exploit this molecular target, a number of potent and specific FLT3 kinase inhibitors have been
I-Shan Hsieh et al.
Molecular pharmacology, 83(5), 968-977 (2013-02-26)
Multidrug resistance is a major cause of chemotherapy failure. Recent studies indicate that drug resistance can be rapidly induced by some soluble factors, such as cytokines, chemokines, growth factors, and cell adhesion factors in the tumor microenvironment. Osteopontin (OPN), an
S Park et al.
Leukemia, 27(7), 1479-1486 (2013-01-17)
The mTORC1 signaling pathway is constitutively activated in almost all acute myelogenous leukemia (AML) patients. We conducted a phase Ib trial combining RAD001 (everolimus), an allosteric inhibitor of mTORC1, and conventional chemotherapy, in AML patients under 65 years of age
Onkar S Bains et al.
The Journal of pharmacology and experimental therapeutics, 347(2), 375-387 (2013-09-03)
The role of metabolism in daunorubicin (DAUN)- and doxorubicin (DOX)-associated toxicity in cancer patients is dependent on whether the parent drugs or major metabolites, doxorubicinol (DOXol) and daunorubicinol (DAUNol), are the more toxic species. Therefore, we examined whether an association
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