1445200

米托蒽醌 二盐酸盐

United States Pharmacopeia (USP) Reference Standard

• 别名: 1,4-二羟基-5,8-双-[[2-[（2-羟乙基）氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐
• 经验公式（希尔记法）: C₂₂H₂₈N₄O₆ · 2HCl
• CAS号: 70476-82-3
• 分子量: 517.40
• MDL號碼: MFCD00242943
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329750478
• NACRES: NA.24

属性

• 等級: pharmaceutical primary standard
• API 家族: mitoxantrone
• 製造商／商標名: USP
• 應用: pharmaceutical (small molecule)
• 格式: neat
• SMILES 字串: Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
• InChI: 1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
• InChI 密鑰: ZAHQPTJLOCWVPG-UHFFFAOYSA-N
• 基因資訊: human ... TOP2A(7153)

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Mitoxantrone hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Mitoxantrone Injection

生化／生理作用

米托蒽醌是一种细胞抑制性蒽二酮，可嵌入 DNA 中，通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物，增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性，抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H340,H360
• 防範說明: P201 - P280 - P308 + P313
• 危險分類: Muta. 1B - Repr. 1B
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable