8.51013

HATU

for peptide synthesis, Novabiochem^®

• 别名: HATU, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate, N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide
• 经验公式（希尔记法）: C₁₀H₁₅N₆O · F₆P
• CAS号: 148893-10-1
• 分子量: 380.23
• MDL號碼: MFCD27957364
• 分類程式碼代碼: 12352107
• NACRES: NA.22

属性

• product name: HATU, Novabiochem^®
• 品質等級: 300
• 產品線: Novabiochem^®
• 形狀: solid
• 反應適用性: reaction type: Coupling Reactions
• 製造商／商標名: Novabiochem^®
• mp: 186 °C (decomposes)
• 應用: peptide synthesis
• 儲存溫度: 2-8°C
• InChI: 1S/C10H15N6O/c1-14(2)10(15(3)4)17-16-9-8(12-13-16)6-5-7-11-9/h5-7H,1-4H3/q+1
• InChI 密鑰: WXIONIWNXBAHRU-UHFFFAOYSA-N

说明

一般說明

A highly efficient coupling reagent for solid and solution phase peptide synthesis. In comparative studies HATU has been found to give better coupling yields with less enantiomerization that HBTU, TBTU or PyBOP^®[1,2,3]. It is particularly effective at coupling to N-alkyl amines where other coupling reagents give poor yields and is the preferred reagent for loading resins bearing secondary amino groups.

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] L. A. Carpino (1993) J. Am. Chem. Soc., 115, 4397.
^[2] F. Albericio, et al. (1998) J. Org. Chem., 63, 9678.
^[3] J. A. Carpino, et al., in "Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium", R. Epton (Ed.), Mayflower Worldwide Ltd., 1994, pp. 95.

聯結

Replaces: 01-62-0041

分析報告

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Identity (NMR, 1H): passes test
Solubility (1 mmole in 2 ml DMF): clearly soluble

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H317 - H334
• 防範說明: P261 - P272 - P280 - P284 - P302 + P352 - P304 + P340 + P312
• 危險分類: Resp. Sens. 1 - Skin Sens. 1
• 儲存類別代碼: 4.1A - Other explosive hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable