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12804

Sigma-Aldrich

苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯

≥98.0% (T), for peptide synthesis

别名:

N,N,N′,N′-四甲基-O-(1H-苯并三氮唑)六氟磷酸脲, HBTU

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About This Item

经验公式（希尔记法）:
C11H16F6N5OP
CAS号:
94790-37-1
分子量:
379.24
Beilstein:
7328329
EC號碼:
423-020-5
MDL號碼:
MFCD00075445
分類程式碼代碼:
12352107
PubChem物質ID:
57647025
NACRES:
NA.22

product name

苯并三氮唑-N,N,N′,N′-四甲基脲六氟磷酸酯, ≥98.0% (T)

品質等級

200

化驗

≥98.0% (T)

形狀

solid

反應適用性

reaction type: Coupling Reactions

mp

200 °C (dec.) (lit.)

溶解度

acetonitrile: 0.1 g/mL, clear

應用

peptide synthesis

儲存溫度

2-8°C

SMILES 字串

F[P-](F)(F)(F)(F)F.CN(C)C(\On1nnc2ccccc12)=[N+](/C)C

InChI

1S/C11H16N5O.F6P/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1

InChI 密鑰

UQYZFNUUOSSNKT-UHFFFAOYSA-N

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相关类别

一般說明

HBTU是一种肽偶联剂，用于基于Fmoc的固相肽合成。

應用

HBTU是用于多肽合成的多肽偶联剂。它也被用于标准Fmoc固相多肽合成（SPPS）方案。
最近研究显示，这种偶联试剂的结晶或溶液结构是胍的 N-氧化物形式，,而不是脲化合物； 用于多肽合成的偶联试剂；优点是：极低的外消旋化，简单的反应条件，非常短的反应时间和高产率。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

危險分類

Skin Sens. 1A

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
BCCG0843
BCCB6870
BCBW2651
BCBQ0174V
BCBL7887V

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Mark Lommel et al.
Scientific reports, 8(1), 11753-11753 (2018-08-08)
Thrombospondins (TSPs) are multidomain glycoproteins with complex matricellular functions in tissue homeostasis and remodeling. We describe a novel role of TSP as a Wnt signaling target in the basal eumetazoan Hydra. Proteome analysis identified Hydra magnipapillata TSP (HmTSP) as a
Héloise Boullet et al.
Molecules (Basel, Switzerland), 24(9) (2019-05-06)
Antimicrobial peptides (AMPs) are considered as potential therapeutic sources of future antibiotics because of their broad-spectrum activities and alternative mechanisms of action compared to conventional antibiotics. Although AMPs present considerable advantages over conventional antibiotics, their clinical and commercial development still
Pritha Agarwalla et al.
Molecular therapy oncolytics, 3, 16020-16020 (2016-08-25)
Recent study has shown that N-end rule pathway, an ubiquitin dependent proteolytic system, counteracts cell death by degrading many antisurvival protein fragments like BCLxL, BRCA1, RIPK1, etc. Inhibition of the N-end rule pathway can lead to metabolic stabilization of proapoptotic
Small molecule approach to studying protein tyrosine phosphatase.
Kumar S, et al.
Methods, 35(1), 9-21 (2005)
One-step 18 F-labeling of peptides for positron emission tomography imaging using the SiFA methodology.
Wangler C, et al.
Nature Protocols, 7(11), 1946-1946 (2012)
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