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Sigma-Aldrich

COMU

≥99.0% (HPLC), for peptide synthesis, Novabiochem®

别名:

COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate

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About This Item

经验公式（希尔记法）:
C12H19F6N4O4P
CAS号:
1075198-30-9
分子量:
428.27
MDL號碼:
MFCD11975052
分類程式碼代碼:
12352107
NACRES:
NA.22

product name

COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®

品質等級

300

產品線

Novabiochem®

化驗

≥99.0% (HPLC)

形狀

powder

反應適用性

reaction type: Coupling Reactions

製造商／商標名

Novabiochem®

mp

>140 °C

應用

peptide synthesis

儲存溫度

15-25°C

InChI

1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;

InChI 密鑰

GPDHNZNLPKYHCN-DZOOLQPHSA-N

相关类别

一般說明

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU [1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated [3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
[2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
[3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.

應用

  • Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).

分析報告

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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商品

Peptide Coupling Reagents Selection Guide

Novabiochem® offers a large number of coupling reagents for in situ activation. In situ activating reagents are easy to use, fast reacting – even with sterically hindered amino acids, and their use is generally free of side reactions.

Peptide Coupling Reagents Selection Guide

Novabiochem® offers a large number of coupling reagents for in situ activation. In situ activating reagents are easy to use, fast reacting – even with sterically hindered amino acids, and their use is generally free of side reactions.

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